N6-methyladenosine (m6A) in pancreatic cancer: Regulatory mechanisms and future direction

被引：24

作者：

Li, Jian ^{[1
,2
]}

Wang, Fangjuan ^{[3
]}

Liu, Yongkang ^{[2
]}

Wang, Huaizhi ^{[4
]}

Ni, Bing ^{[1
]}

机构：

[1] Third Mil Med Univ, Army Med Univ, Coll High Altitude, Dept Pathophysiol, Chongqing 400038, Peoples R China

[2] Air Force Hosp Western Theater Command, Dept Gen Surg, Chengdu 610021, Peoples R China

[3] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Cardiol, Chongqing 400038, Peoples R China

[4] Univ Chinese Acad Sci, Chongqing Gen Hosp, Inst Hepatopancreatobiliary Surg, Chongqing 401120, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2021年 / 17卷 / 09期

关键词：

m(6)A; Pancreatic cancer; RNA modification; clinical application; MESSENGER-RNA METHYLATION; CIRCULATING TUMOR-CELLS; BODY-MASS INDEX; METTL3; PROMOTES; UP-REGULATION; SELF-RENEWAL; NUCLEAR-RNA; YTH DOMAIN; FAT MASS; DEMETHYLASE;

D O I：

10.7150/ijbs.60115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-6-methyladenosine (m(6)A), the most abundant RNA modification in eukaryotes, plays a pivotal role in regulating many cellular and biological processes. Aberrant m(6)A modification has recently been involved in carcinogenesis in various cancers, including pancreatic cancer. Pancreatic cancer is one of the deadliest cancers. It is a heterogeneous malignant disease characterized by a plethora of diverse genetic and epigenetic events. Increasing evidence suggests that dysregulation of m(6)A regulatory factors, such as methyltransferases, demethylases, and m(6)A-binding proteins, profoundly affects the development and progression of pancreatic cancer. In addition, m(6)A regulators and m(6)A target transcripts may be promising early diagnostic and prognostic cancer biomarkers, as well as therapeutic targets. In this review, we highlight the biological functions and mechanisms of m(6)A in pancreatic cancer and discuss the potential of m(6)A modification in clinical applications.

引用

页码：2323 / 2335

页数：13

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