Comparative case-control study of homocysteine, vitamin B12, and folic acid levels in patients with epilepsy

被引：10

作者：

Pulido Fontes, L. ^{[1
,2
]}

Putido Fontes, M. ^{[1
]}

Quesada Jimenez, P. ^{[1
]}

Muruzabat Perez, J. ^{[1
]}

Mendioroz Iriarte, M. ^{[1
,2
]}

机构：

[1] Complejo Hosp Navarra, Serv Neurol, Pamplona, Navarra, Spain

[2] Lab Neuroepigenet Navarrabiomed IdiSNA, Pamplona, Navarra, Spain

来源：

NEUROLOGIA | 2017年 / 32卷 / 07期

关键词：

Hyperhomocysteinae-mia; Folic acid; Vitamin B-12; Epilepsy; Antiepileptic drugs; Cardiovascular risk; DRUG-RESISTANT EPILEPSY; ANTIEPILEPTIC DRUGS; B-VITAMINS; SERUM-LEVELS; HYPERHOMOCYSTEINEMIA; METABOLISM; SUPPLEMENTATION; GUIDELINES; DISEASES; FOLATE;

D O I：

10.1016/j.nrl.2016.02.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Increased blood homocysteine levels are a known cardiovascular risk factor. Epileptic patients on long-term treatment with antiepileptic drugs may present higher homocysteine levels and, consequently, a potential increase in cardiovascular risk. Material and methods: We conducted an observational case-control study to compare plasma levels of homocysteine, folic acid, and vitamin B-12. Results: Our study included a total of 88 subjects: 52 patients with epilepsy and 36 controls. Epileptic patients showed higher homocysteine levels (P=.084) and lower levels of folic acid (P<.05). Conclusion: Homocysteine levels should be monitored in epileptic patients on long-term treatment with antiepileptic drugs. We suggest starting specific treatment in patients with high homocysteine levels. (C) 2016 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U.

引用

页码：440 / 445

页数：6

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