Chlorpromazine-impregnated catheters as a potential strategy to control biofilm-associated urinary tract infections

被引：21
作者：
Sidrim, Jose J. C. [1 ]
Amando, Bruno R. [2 ]
Gomes, Francisco I. F. [2 ]
Amaral, Marilia S. M. G. [2 ]
de Sousa, Paulo C. P. [3 ]
Ocadaque, Crister J. [2 ]
Brilhante, Raimunda S. N. [1 ]
Cordeiro, Rossana de A. [1 ]
Rocha, Marcos F. G. [1 ,4 ]
Castelo-Branco, Debora de S. C. M. [1 ,2 ]
机构：
[1] Univ Fed Ceara, Specialized Med Mycol Ctr, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Rua Cel Nunes de Melo,1315 Rodolfo Teofilo, BR-60430275 Fortaleza, Ceara, Brazil
[2] Univ Fed Ceara, Dept Pathol & Legal Med, Postgrad Program Med Microbiol, Grp Appl Med Microbiol, Rua Cel Nunes de Melo,1315 Rodolfo Teofilo, BR-60430275 Fortaleza, Ceara, Brazil
[3] Walter Cantidio Univ Hosp, Rua Cel Nunes de Melo,1315 Rodolfo Teofilo, BR-60430372 Fortaleza, Ceara, Brazil
[4] Univ Estadual Ceara, Coll Vet, Av Dr Silas Munguba 1700,Campus Itaperi, BR-60714903 Fortaleza, Ceara, Brazil
来源：
FUTURE MICROBIOLOGY | 2019年 / 14卷 / 12期
关键词：
biofilms; catheter impregnation; chlorpromazine; efflux-pump inhibitor; uropathogens; MULTIDRUG EFFLUX PUMPS; ANTIMICROBIAL SUSCEPTIBILITY; BURKHOLDERIA-PSEUDOMALLEI; INHIBITION; MECHANISMS; INCREASES; RESISTANT; BACTERIA;
D O I：
10.2217/fmb-2019-0092
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study proposes the impregnation of Foley catheters with chlorpromazine (CPZ) to control biofilm formation by Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae. Materials & methods: The minimum inhibitory concentrations (MICs) for CPZ and the effect of CPZ on biofilm formation were assessed. Afterward, biofilm formation and the effect of ciprofloxacin and meropenem (at MIC) on mature biofilms grown on CPZ-impregnated catheters were evaluated. Results: CPZ MIC range was 39.06-625 mg/l. CPZ significantly reduced (p < 0.05) biofilm formation in vitro and on impregnated catheters. In addition, CPZ-impregnation potentiated the antibiofilm activity of ciprofloxacin and meropenem. Conclusion: These findings bring perspectives for the use of CPZ as an adjuvant for preventing and treating catheter-associated urinary tract infections.
引用
收藏
页码：1023 / 1034
页数：12
相关论文
共 40 条
  • [1] EFFECTS OF CHLORPROMAZINE ON THE CELL-ENVELOPE PROTEINS OF ESCHERICHIA-COLI
    AMARAL, L
    LORIAN, V
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (09) : 1923 - 1924
  • [2] 2012 and beyond: potential for the start of a second pre-antibiotic era?
    Appelbaum, Peter C.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (09) : 2062 - 2068
  • [3] Inhibition of multidrug efflux as a strategy to prevent biofilm formation
    Baugh, Stephanie
    Phillips, Charlotte R.
    Ekanayaka, Aruna S.
    Piddock, Laura J. V.
    Webber, Mark A.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (03) : 673 - 681
  • [4] Blair JMA, 2014, FUTURE MICROBIOL, V9, P1165, DOI [10.2217/FMB.14.66, 10.2217/fmb.14.66]
  • [5] Biofilm Antimicrobial Susceptibility Increases With Antimicrobial Exposure Time
    Castaneda, Paulo
    McLaren, Alex
    Tavaziva, Gamuchirai
    Overstreet, Derek
    [J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2016, 474 (07) : 1659 - 1664
  • [6] Farnesol increases the susceptibility of Burkholderia pseudomallei biofilm to antimicrobials used to treat melioidosis
    Castelo-Branco, D. S. C. M.
    Riello, G. B.
    Vasconcelos, D. C.
    Guedes, G. M. M.
    Serpa, R.
    Bandeira, T. J. P. G.
    Monteiro, A. J.
    Cordeiro, R. A.
    Rocha, M. F. G.
    Sidrim, J. J. C.
    Brilhante, R. S. N.
    [J]. JOURNAL OF APPLIED MICROBIOLOGY, 2016, 120 (03) : 600 - 606
  • [7] Preventing Catheter-Associated Urinary Tract Infections in the Intensive Care Unit
    Chenoweth, Carol
    Saint, Sanjay
    [J]. CRITICAL CARE CLINICS, 2013, 29 (01) : 19 - +
  • [8] Clinical and Laboratory Standards Institute, 2017, M100S27 CLSI
  • [9] Promethazine improves antibiotic efficacy and disrupts biofilms of Burkholderia pseudomallei
    Costa Sidrim, Jose Julio
    Vasconcelos, David Caldas
    Riello, Giovanna Barbosa
    de Melo Guedes, Glaucia Morgana
    Serpa, Rosana
    Pinheiro Gomes Bandeira, Tereza de Jesus
    Monteiro, Andre Jalles
    Cordeiro, Rossana de Aguiar
    Collares Maia Castelo-Branco, Debora de Souza
    Gadelha Rocha, Marcos Fabio
    Nogueira Brilhante, Raimunda Samia
    [J]. BIOFOULING, 2017, 33 (01) : 88 - 97
  • [10] Increasing of the Aminoglicosyde Antibiotic Activity Against a Multidrug-Resistant E. coli by Turnera ulmifolia L. and Chlorpromazine
    Coutinho, Henrique D. M.
    Costa, Jose G. M.
    Lima, Edeltrudes O.
    Falcao-Silva, Vivyanne S.
    Siqueira-Junior, Jose P.
    [J]. BIOLOGICAL RESEARCH FOR NURSING, 2010, 11 (04) : 332 - 335
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