Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system

被引：22
作者：
Brulois, Kevin [1 ]
Jung, Jae U. [1 ]
机构：
[1] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 05期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
KSHV; Innate immunity; NF-KAPPA-B; INTERFERON REGULATORY FACTORS; PATTERN-RECOGNITION RECEPTORS; NOTCH SIGNAL-TRANSDUCTION; FLICE INHIBITORY PROTEIN; DNA-DAMAGE RESPONSE; ENDOTHELIAL-CELLS; DOWN-REGULATION; I INTERFERON; INFLAMMATORY CYTOKINES;
D O I：
10.1016/j.cytogfr.2014.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding of the innate immune response to viral infections is rapidly progressing, especially with regards to the detection of DNA viruses. Kaposi's sarcoma-associated herpesvirus (KSHV) is a large dsDNA virus that is responsible for three human diseases: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. The major target cells of KSHV (B cells and endothelial cells) express a wide range of pattern recognition receptors (PRRs) and play a central role in mobilizing inflammatory responses. On the other hand, KSHV encodes an array of immune evasion genes, including several pirated host genes, which interfere with multiple aspects of the immune response. This review summarizes current understanding of innate immune recognition of KSHV and the role of immune evasion genes that shape the antiviral and inflammatory responses. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：597 / 609
页数：13
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