Multifunctional Nanorobot System for Active Therapeutic Delivery and Synergistic Chemo-photothermal Therapy

被引：78

作者：

Jin, Zhen ^{[1
,2
]}

Kim Tien Nguyen ^{[1
,2
]}

Go, Gwangjun ^{[1
,2
]}

Kang, Bungjeon ^{[1
]}

Min, Hyun-Ki ^{[1
]}

Kim, Seok-Jae ^{[1
]}

Kim, Yun ^{[3
]}

Li, Hao ^{[1
]}

Kim, Chang-Sei ^{[1
,2
]}

Lee, Seonmin ^{[4
]}

Park, Sukho ^{[5
]}

Kim, Kyu-Pyo ^{[4
]}

Huh, Kang Moo ^{[6
]}

Song, Jihwan ^{[3
]}

Park, Jong-Oh ^{[1
,2
]}

Choi, Eunpyo ^{[1
,2
]}

机构：

[1] Korea Inst Med Microrobot, 43-26 Cheomdangwagi Ro, Gwangju 61011, South Korea

[2] Chonnam Natl Univ, Sch Mech Engn, 77 Yongbong Ro, Gwangju 61186, South Korea

[3] Hanbat Natl Univ, Dept Mech Engn, Daejeon 34158, South Korea

[4] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, 88 Olymp Ro,43 Gil, Seoul 05505, South Korea

[5] DGIST, Dept Robot Engn, Daegu 42988, South Korea

[6] Chungnam Natl Univ, Dept Polymer Sci & Engn, 99 Daehak Ro, Daejeon 34134, South Korea

来源：

NANO LETTERS | 2019年 / 19卷 / 12期

关键词：

Nanorobot system; active tumor targeting; controlled drug release; chemo-photothermal therapy; cancer treatment; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; CANCER; NANOMOTORS; BACTERIA; TRANSPORTATION; NANOLIPOSOMES; HYPERTHERMIA; CHEMOTHERAPY; GUIDANCE;

D O I：

10.1021/acs.nanolett.9b03051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanorobots are safe and exhibit powerful functionalities, including delivery, therapy, and diagnosis. Therefore, they are in high demand for the development of new cancer therapies. Although many studies have contributed to the progressive development of the nanorobot system for anticancer drug delivery, these systems still face some critical limitations, such as potentially toxic materials in the nanorobots, unreasonable sizes for passive targeting, and the lack of several essential functions of the nanorobot for anticancer drug delivery including sensing, active targeting, controlling drug release, and sufficient drug loading capacity. Here, we developed a multifunctional nanorobot system capable of precise magnetic control, sufficient drug loading for chemotherapy, light-triggered controlled drug release, light absorption for photothermal therapy, enhanced magnetic resonance imaging, and tumor sensing. The developed nanorobot system exhibits an in vitro synergetic antitumor effect of photothermal therapy and chemotherapy and outstanding tumor-targeting efficiency in both in vitro and in vivo environments. The results of this study encourage further explorations of an efficient active drug delivery system for cancer treatment and the development of nanorobot systems for other biomedical applications.

引用

页码：8550 / 8564

页数：15

共 59 条

[1] Concentration-Dependent Induction of Reactive Oxygen Species, Cell Cycle Arrest and Apoptosis in Human Liver Cells After Nickel Nanoparticles Exposure [J].