Ivabradine for systolic heart failure

被引：2
作者：
Meade, Courtney M. [1 ]
Clements, Jennifer N. [2 ]
机构：
[1] Presbyterian Coll, Sch Pharm, Clinton, NY 29325 USA
[2] Presbyterian Coll, Sch Pharm, Pharm Practice, Clinton, NY USA
来源：
JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS | 2018年 / 31卷 / 03期
关键词：
hyperpolarization-activated cyclic nucleotidegated channel inhibitor; ivabradine; hospitalization; heart failure; systolic heart failure; depolarization; CORONARY-ARTERY-DISEASE; SHIFT; EFFICACY; SAFETY;
D O I：
10.1097/01.JAA.0000530305.69021.02
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ivabradine works in the sinoatrial node to prolong dia-stolic depolarization and reduce heart rate. In patients with chronic systolic heart failure, this drug has reduced the risk of hospitalization when used in combination with other optimal pharmacotherapy.
引用
收藏
页码：52 / 54
页数：3
相关论文
共 11 条
[1]  
American Heart Association, HEART FAILURE
[2]  
[Anonymous], 2015, CORLANOR PRESCRIBING
[3]   Efficacy and Safety of Ivabradine in Patients With Severe Chronic Systolic Heart Failure (from the SHIFT Study) [J].
Borer, Jeffrey S. ;
Boehm, Michael ;
Ford, Ian ;
Robertson, Michele ;
Komajda, Michel ;
Tavazzi, Luigi ;
Swedberg, Karl .
AMERICAN JOURNAL OF CARDIOLOGY, 2014, 113 (03) :497-503
[4]   Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study [J].
Borer, Jeffrey S. ;
Boehm, Michael ;
Ford, Ian ;
Komajda, Michel ;
Tavazzi, Luigi ;
Lopez Sendon, Jose ;
Alings, Marco ;
Lopez-de-Sa, Esteban ;
Swedberg, Karl .
EUROPEAN HEART JOURNAL, 2012, 33 (22) :2813-2820
[5]   Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial [J].
Fox, Kim ;
Ford, Ian ;
Steg, P. Gabriel ;
Tendera, Michal ;
Ferrari, Roberto .
LANCET, 2008, 372 (9641) :807-816
[6]   Ivabradine in Stable Coronary Artery Disease without Clinical Heart Failure [J].
Fox, Kim ;
Ford, Ian ;
Steg, Philippe Gabriel ;
Tardif, Jean-Claude ;
Tendera, Michal ;
Ferrari, Roberto .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (12) :1091-1099
[7]  
Isakadze A, 2015, Georgian Med News, P44
[8]   Efficacy and safety of ivabradine in patients with chronic systolic heart failure according to blood pressure level in SHIFT [J].
Komajda, Michel ;
Boehm, Michael ;
Borer, Jeffrey S. ;
Ford, Ian ;
Robertson, Michele ;
Manolis, Athanasios J. ;
Tavazzi, Luigi ;
Swedberg, Karl .
EUROPEAN JOURNAL OF HEART FAILURE, 2014, 16 (07) :810-816
[9]   Atrial fibrillation associated with ivabradine treatment: meta-analysis of randomised controlled trials [J].
Martin, Ruairidh I. R. ;
Pogoryelova, Oksana ;
Koref, Mauro Santibanez ;
Bourke, John P. ;
Teare, M. Dawn ;
Keavney, Bernard D. .
HEART, 2014, 100 (19) :1506-1510
[10]   An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure [J].
Rosa, Gian Marco ;
Ferrero, Simone ;
Ghione, Paola ;
Valbusa, Alberto ;
Brunelli, Claudio .
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2014, 10 (02) :279-291
12