Induced Pluripotent Stem Cells at Nanoscale

被引：33

作者：

Zeuschner, Dagmar ^{[1
]}

Mildner, Karina ^{[1
]}

Zaehres, Holm ^{[1
]}

Schoeler, Hans R. ^{[1
]}

机构：

[1] Max Planck Inst Mol Biomed, Dept Cell & Dev Biol, D-48149 Munster, Nrw, Germany

来源：

STEM CELLS AND DEVELOPMENT | 2010年 / 19卷 / 05期

关键词：

MITOCHONDRIA; FIBROBLASTS;

D O I：

10.1089/scd.2009.0159

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been made possible with the expression of the transcription factor quartet Oct4, Sox2, c-Myc, and Klf4. Here, we compared iPS cells derived from mouse embryonic fibroblasts with the 4 factors to embryonic stem cells by electron microscopy. Both cell types are almost indistinguishable at the ultrastructural level, providing further evidence for the similarity of these 2 pluripotent stem cell populations.

引用

页码：615 / 620

页数：6

共 15 条

[1] Mitochondria: Dynamic organelles in disease, aging, and development [J].

Chan, David C. .

CELL, 2006, 125 (07) :1241-1252

[2] Organization of chromatin in the interphase mammalian cell [J].

Dehghani, H ;

Dellaire, G ;

Bazett-Jones, DP .

MICRON, 2005, 36 (02) :95-108

[3] The Dynamin Related Protein Dnm1 Fragments Mitochondria in a Microtubule-Dependent Manner During The Fission Yeast Cell Cycle [J].

Jourdain, Isabelle ;

Gachet, Yannick ;

Hyams, Jeremy S. .

CELL MOTILITY AND THE CYTOSKELETON, 2009, 66 (08) :509-523

[4] Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors [J].

Kim, Jeong Beom ;

Zaehres, Holm ;

Wu, Guangming ;

Gentile, Luca ;

Ko, Kinarm ;

Sebastiano, Vittorio ;

Arauzo-Bravo, Marcos J. ;

Ruau, David ;

Han, Dong Wook ;

Zenke, Martin ;

Schoeler, Hans R. .

NATURE, 2008, 454 (7204) :646-U54

[5] Generation of germline-competent induced pluripotent stem cells [J].

Okita, Keisuke ;

Ichisaka, Tomoko ;

Yamanaka, Shinya .

NATURE, 2007, 448 (7151) :313-U1

[6]

Park IH, 2008, NATURE, V451, P141, DOI [10.1038/nature06534, 10.1038/natureO6534]

[7] Endocytosis conducts the cell signaling orchestra [J].

Polo, S ;

Di Fiore, PP .

CELL, 2006, 124 (05) :897-900

[8] Building the cell: design principles of cellular architecture [J].

Rafelski, Susanne M. ;

Marshall, Wallace F. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (08) :593-602

[9] Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains [J].

Riemann, D ;

Hansen, GH ;

Niels-Christiansen, LL ;

Thorsen, E ;

Immerdal, L ;

Santos, AN ;

Kehlen, A ;

Langner, J ;

Danielsen, EM .

BIOCHEMICAL JOURNAL, 2001, 354 :47-55

[10] Allele-specific expression of imprinted genes in mouse migratory primordial germ cells [J].

Szabó, PE ;

Hübner, K ;

Schöler, H ;

Mann, JR .

MECHANISMS OF DEVELOPMENT, 2002, 115 (1-2) :157-160

← 1 2 →