Neurology and the COVID-19 Pandemic Gathering Data for an Informed Response

被引:6
作者
High, Brigit [1 ,2 ]
Hixon, Alison M. [1 ]
Tyler, Kenneth L. [3 ]
Piquet, Amanda L. [3 ]
Pelak, Victoria S. [3 ,4 ]
机构
[1] Univ Colorado, Med Scientist Training Program, Sch Med, Aurora, CO USA
[2] Univ Colorado, Rocky Mt Taste & Smell Ctr, Sch Med, Aurora, CO USA
[3] Univ Colorado, Dept Neurol, Sch Med, Aurora, CO 80045 USA
[4] Univ Colorado, Dept Ophthalmol, Sch Med, Aurora, CO 80045 USA
关键词
RESPIRATORY SYNDROME CORONAVIRUS; DISEASE; 2019; COVID-19; PERSISTENT INFECTION; SARS CORONAVIRUS; CYTOKINE STORM; CELL-LINES; RECEPTOR; BRAIN; ACE2; PATHOGENESIS;
D O I
10.1212/CPJ.0000000000000908
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose of Review The current coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the greatest medical crises faced by our current generation of health care providers. Although much remains to be learned about the pathophysiology of SARS-CoV-2, there is both historical precedent from other coronaviruses and a growing number of case reports and series that point to neurologic consequences of COVID-19. Recent Findings Olfactory/taste disturbances and increased risk of strokes and encephalopathies have emerged as potential consequences of COVID-19 infection. Evidence regarding whether these sequelae result indirectly from systemic infection or directly from neuroinvasion by SARS-CoV-2 is emerging. Summary This review summarizes the current understanding of SARS-CoV-2 placed in context with our knowledge of other human coronaviruses. Evidence and data regarding neurologic sequelae of COVID-19 and the neuroinvasive potential of human coronaviruses are provided along with a summary of patient registries of interest to the Neurology community.
引用
收藏
页码:E48 / E63
页数:16
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