Epithelial plasticity in prostate cancer: principles and clinical perspectives

被引：21

作者：

Das, Rajdeep ^{[1
,2
,3
,4
]}

Gregory, Philip A. ^{[4
,5
,6
]}

Hollier, Brett G. ^{[7
]}

Tilley, Wayne D. ^{[1
,2
,3
,4
]}

Selth, Luke A. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Adelaide, Dame Roma Mitchell Canc Res Labs, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Adelaide Prostate Canc Res Ctr, Adelaide, SA 5005, Australia

[3] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia

[4] Univ Adelaide, Discipline Med, Adelaide, SA 5005, Australia

[5] Univ S Australia, Ctr Canc Biol, Div Human Immunol, Adelaide, SA 5001, Australia

[6] SA Pathol, Adelaide, SA, Australia

[7] Queensland Univ Technol, Princess Alexandra Hosp, Australian Prostate Canc Res Ctr Queensland, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 11期

关键词：

epithelial plasticity; epithelial-mesenchymal transition; mesenchymal-epithelial transition; androgen receptor; androgen deprivation therapy; chemotherapy; CIRCULATING TUMOR-CELLS; TO-MESENCHYMAL TRANSITION; ANDROGEN RECEPTOR; STEM-CELLS; E-CADHERIN; CASTRATION RESISTANCE; DOCETAXEL RESISTANCE; BREAST-CANCER; METASTATIC COLONIZATION; BIOCHEMICAL RECURRENCE;

D O I：

10.1016/j.molmed.2014.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past decade, the capacity of cancer cells to oscillate between epithelial and mesenchymal phenotypes, termed epithelial plasticity (EP), has been demonstrated to play a critical role in metastasis. This phenomenon may be particularly important for prostate cancer (PC) progression, since recent studies have revealed interplay between EP and signaling by the androgen receptor (AR) oncoprotein. Moreover, EP appears to play a role in dictating the response to therapies for metastatic PC. This review will evaluate preclinical and clinical evidence for the relevance of EP in PC progression and consider the potential of targeting and measuring EP as a means to treat and manage lethal forms of the disease.

引用

页码：643 / 651

页数：9

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