Spoligotyping of Mycobacterium tuberculosis isolates from Pulmonary Tuberculosis patients from North Karnataka, India

被引：1

作者：

Bellad, Reshma ^{[1
]}

Nagamoti, Mahantesh ^{[1
]}

Sharma, Pragya ^{[2
]}

Chauhan, D. S. ^{[3
]}

机构：

[1] KAHER, JNMC, Dept Microbiol, Belgavai 590010, Karnataka, India

[2] Natl Inst Canc Prevent & Res, Noida, Uttar Pradesh, India

[3] Natl JALMA Inst Leprosy & Other Mycobacterial Dis, Agra, Uttar Pradesh, India

来源：

TROPICAL DOCTOR | 2022年 / 52卷 / 03期

关键词：

Tuberculosis disease; epidemiology disease; Indian Ocean Islands location; DRUG-RESISTANCE; DIVERSITY; GENOTYPE; SPREAD; STRAIN;

D O I：

10.1177/00494755221080584

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Tuberculosis (TB) is a leading cause of morbidity and mortality in low income countries. Multi-drug resistant (MDR-TB) is seen as the reason for many TB outbreaks globally and is also a threat to control programmes. India accounts for 27% TB cases worldwide. Our study was undertaken to understand the outbreaks related to MTB. All the sputum samples were subjected to microscopy and smear positive samples were cultured on Lowenstein-Jensen (L-J) media. Identification was carried by biochemical analysis. A total of 57 isolates were subjected to Drug Susceptibility testing (DST) and spoligotyping, where eleven MDR-TB isolates were confirmed, of which ten were SIT1/Beijing and one SIT53/T1. Spoligotyping results showed that the predominant lineage in this region was SIT1/Beijing followed by SIT124/U and the strains which did not match spoligodatabase were named as orphans. In this study, MDR-TB was associated with SIT1/Beijing and mono resistance belonged to CAS1_DEL.

引用

页码：386 / 390

页数：5

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