Near-infrared fluorescence imaging-guided surgery improves recurrence-free survival rate in novel orthotopic animal model of head and neck squamous cell carcinoma

被引：32

作者：

Atallah, Ihab ^{[1
,2
,3
]}

Milet, Clement ^{[1
,2
]}

Henry, Maxime ^{[1
,2
]}

Josserand, Veronique ^{[1
,2
]}

Reyt, Emile ^{[2
,3
]}

Coll, Jean-Luc ^{[1
,2
]}

Hurbin, Amandine ^{[1
,2
]}

Righini, Christian Adrien ^{[1
,2
,3
]}

机构：

[1] INSERM, U823, Grenoble, France

[2] Univ Grenoble 1, Grenoble, France

[3] Grenoble Univ Hosp, Dept Otolaryngol Head & Neck Surg, BP 217, Grenoble, France

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷

关键词：

head and neck squamous cell carcinoma; orthotopic animal model; near-infrared optical imaging-guided surgery; alpha(v)beta(3) integrin; surgical margins; INTEGRIN ALPHA(V)BETA(3); CANCER MODEL; ORAL-CANCER; K-RAS; COMBINATION; IRRADIATION; ANGIOGENESIS; PERMEABILITY; INHIBITION; EXPRESSION;

D O I：

10.1002/hed.23980

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Appropriate animal models are required to test novel therapeutics for head and neck squamous cell carcinoma (HNSCC) such as near-infrared (NIR) imaging-guided surgery. Methods. We developed an optimized animal model of orthotopic HNSCC (in female athymic NMRI (Naval Medical Research Institute) nude mice) with a prolonged survival time. Resection of the orthotopic tumors was performed 30 days after implantation with or without the aid of a miniaturized clinical grade NIR optical imaging device, after systemic administration of a fluorescent RGD-based probe that targets alpha(v)beta(3) integrin. Results. NIR optical imaging-guided surgery increased the recurrencefree survival rate by 50% through the detection of fluorescent cancer residues as small as 185 mm; these fragments could remain unidentified if resection was performed exclusively under unaided visual guidance. Conclusion. NIR optical imaging-guided surgery showed an improved HNSCC tumor resection quality in our optimized orthotopic animal model. (C) 2015 Wiley Periodicals, Inc.

引用

页码：E246 / E255

页数：10

共 47 条

[1] Neuropilin-1 expression in squamous cell carcinoma of the oesophagus [J].

Alattar, Mohamed ;

Omo, Alfred ;

Elsharawy, Mamdouh ;

Li, Jun .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 45 (03) :514-520

[2]

Aubry K, 2008, IN VIVO, V22, P403

[3] Insulin-like growth factor receptor as a therapeutic target in head and neck cancer [J].

Barnes, Christopher J. ;

Ohshiro, Kazufumi ;

Rayala, Suresh K. ;

El-Naggar, Adel K. ;

Kumar, Rakesh .

CLINICAL CANCER RESEARCH, 2007, 13 (14) :4291-4299

[4] Template assembled cyclopeptides as multimeric system for integrin targeting and endocytosis [J].

Boturyn, D ;

Coll, JL ;

Garanger, E ;

Favrot, MC ;

Dumy, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (18) :5730-5739

[5] Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model [J].

Bozec, A. ;

Sudaka, A. ;

Fischel, J-L ;

Brunstein, M-C ;

Etienne-Grimaldi, M-C ;

Milano, G. .

BRITISH JOURNAL OF CANCER, 2008, 99 (01) :93-99

[6] Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts [J].

Bozec, A. ;

Formento, P. ;

Lassalle, S. ;

Lippens, C. ;

Hofman, P. ;

Milano, G. .

BRITISH JOURNAL OF CANCER, 2007, 97 (01) :65-72

[7] Combination of sunitinib, cetuximab and irradiation in an orthotopic head and neck cancer model [J].

Bozec, A. ;

Sudaka, A. ;

Toussan, N. ;

Fischel, J.-L. ;

Etienne-Grimaldi, M.-C. ;

Milano, G. .

ANNALS OF ONCOLOGY, 2009, 20 (10) :1703-1707

[8] Antitumor activity of cetuximab associated with the taxotere-cisplatin-fluorouracil (TPF) combination on an orthotopic head and neck cancer model [J].

Bozec, Alexandre ;

Sudaka, Anne ;

Etienne-Grimaldi, Marie-Christine ;

Brunstein, Marie-Christine ;

Fischel, Jean-Louis ;

Milano, Gerard .

ORAL ONCOLOGY, 2011, 47 (10) :940-945

[9] Orthotopic murine model of head and neck squamous cell carcinoma [J].

Cabanillas, R. ;

Secades, P. ;

Rodrigo, J. P. ;

Astudillo, A. ;

Suarez, C. ;

Chiara, M. D. .

ACTA OTORRINOLARINGOLOGICA ESPANOLA, 2005, 56 (03) :89-95

[10] Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity [J].

Caulin, C ;

Nguyen, T ;

Longley, MA ;

Zhou, ZJ ;

Wang, XJ ;

Roop, DR .

CANCER RESEARCH, 2004, 64 (15) :5054-5058

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