Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC)

被引：15
作者：
Liu, Shiyi [1 ]
Li, Saijiao [2 ]
Wang, Yanqing [1 ]
Wang, Feiyan [1 ]
Zhang, Li [1 ]
Xian, Shu [1 ]
Yang, Dongyong [1 ]
Yuan, Mengqin [1 ]
Dai, Fangfang [1 ]
Zhao, Xin [1 ]
Liu, Yuping [1 ]
Jin, Yumeng [1 ]
Zeng, Zihang [3 ]
Mahgoub, Omer Kamal Ahmed [1 ]
Zhou, Chenliang [4 ]
Cheng, Yanxiang [1 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Obstet & Gynecol, JieFang Rd 238, Wuhan 430060, Hubei, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Reprod Med Ctr, Wuhan 430060, Hubei, Peoples R China
[3] Wuhan Univ, Zhongnan Hosp, Dept Tumor Ctr, Wuhan 430071, Hubei, Peoples R China
[4] Wuhan Univ, Renmin Hosp, Dept Crit Care Med Ctr, JieFang Rd 238, Wuhan 430060, Hubei, Peoples R China
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2020年 / 121卷 / 03期
关键词：
immunotherapy; mutation; prognosis; TCGA; tumor microenvironment; CANCER; THERAPY;
D O I：
10.1002/jcb.29479
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the "Estimation of STromal and Immune cells in MAlignant Tumours using Expression data" algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.
引用
收藏
页码：2571 / 2581
页数：11
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