Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran

被引：76

作者：

Hashemi, M. ^{[1
,2
]}

Moazeni-Roodi, A. K. ^{[3
]}

Fazaeli, A. ^{[4
]}

Sandoughi, M. ^{[5
]}

Bardestani, G. R. ^{[5
]}

Kordi-Tamandani, D. M. ^{[3
]}

Ghavami, S. ^{[6
]}

机构：

[1] Zahedan Univ Med Sci, Sch Med, Dept Clin Biochem, Zahedan, Iran

[2] Zahedan Univ Med Sci, Cellular & Mol Res Ctr, Zahedan, Iran

[3] Sistam & Baluchistan Univ, Fac Sci, Dept Biol, Zahedan, Iran

[4] Zanjan Univ Med Sci, Sch Med, Dept Parasitol, Zanjan, Iran

[5] Zahedan Univ Med Sci, Sch Med, Dept Internal Med, Zahedan, Iran

[6] Univ Manitoba, Dept Physiol, Manitoba Inst Child Hlth, Winnipeg, MB, Canada

来源：

GENETICS AND MOLECULAR RESEARCH | 2010年 / 9卷 / 01期

关键词：

Paraoxonase; PON1; Q192R polymorphism; Rheumatoid arthritis; HIGH-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE; ALZHEIMERS-DISEASE; REACTIVE OXYGEN; ARYLESTERASE; ESTERASE; SYSTEM; PON1; OXIDATION; DECREASE;

D O I：

10.4238/vol9-1gmr728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q192R polymorphism in 88 rheumatoid arthritis patients and 78 healthy subjects was determined using tetra amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and PCR-restriction fragment length polymorphism (RFLP) methods. We found no significant differences between rheumatoid arthritis patients and control subjects regarding PON1 Q192R polymorphism. PON1 Q192R polymorphism was not found to be correlated with increased risk for rheumatoid arthritis in this Iranian population.

引用

页码：333 / 339

页数：7

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