Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases

被引：70

作者：

Sparks, Jeffrey A. ^{[1
]}

Costenbader, Karen H. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol Immunol & Allergy,Dept Med, Boston, MA 02115 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2014年 / 40卷 / 04期

关键词：

Rheumatoid arthritis; Systemic lupus erythematosus; Ankylosing spondylitis; Environment; Genetics; Interaction; Smoking; GENOME-WIDE ASSOCIATION; HLA-DRB1 SHARED EPITOPE; EPSTEIN-BARR-VIRUS; BODY-MASS INDEX; LUPUS-ERYTHEMATOSUS; CIGARETTE-SMOKING; ANKYLOSING-SPONDYLITIS; RISK-FACTORS; DNA METHYLATION; REVISED CRITERIA;

D O I：

10.1016/j.rdc.2014.07.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatic diseases offer distinct challenges to researchers because of heterogeneity in disease phenotypes, low disease incidence, and geographic variation in genetic and environmental factors. Emerging research areas, including epigenetics, metabolomics, and the microbiome, may provide additional links between genetic and environmental risk factors in the pathogenesis of rheumatic disease. This article reviews the methods used to establish genetic and environmental risk factors and studies gene-environment interactions in rheumatic diseases, and provides specific examples of successes and challenges in identifying gene-environment interactions in rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis. Emerging research strategies and future challenges are discussed.

引用

页码：637 / +

页数：22

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