Clinical biomarkers in sickle cell disease

被引：39
|
作者：
Damanhouri, Ghazi A. [1 ]
Jarullah, Jummanah [1 ]
Marouf, Samy [2 ]
Hindawi, S. I. [1 ]
Mushtaq, Gohar [3 ]
Kamal, Mohammad A. [4 ]
机构：
[1] King Abdulaziz Univ, King Fahd Med Res Ctr, Hematol Res Lab, Jeddah 21589, Saudi Arabia
[2] King Fahd Armed Forces Hosp, Jeddah, Saudi Arabia
[3] King Abdulaziz Univ, Coll Sci, Dept Biochem, Jeddah 21589, Saudi Arabia
[4] King Abdulaziz Univ, King Fahd Med Res Ctr, Metabol & Enzymol Unit, Jeddah 21589, Saudi Arabia
来源：
SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2015年 / 22卷 / 01期
关键词：
Biomarkers; Polymerization; Sickle cell disease; Vaso-occlusion; Reticulocytes count; Hypercoagulability; ACUTE CHEST SYNDROME; SECRETORY PHOSPHOLIPASE A(2); C-REACTIVE PROTEIN; PULMONARY-HYPERTENSION; LACTATE-DEHYDROGENASE; FETAL-HEMOGLOBIN; RISK-FACTORS; CHILDREN; ANEMIA; ADULTS;
D O I：
10.1016/j.sjbs.2014.09.005
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene. Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history. Biomarkers have been proven helpful in identifying different interconnected disease-causing mechanisms of SCD, including hypercoagulability, hemolysis, inflammation, oxidative stress, vasculopathy, reperfusion injury and reduced vasodilatory responses in endothelium, to name just a few. However, there exists a need to establish a panel of validated blood and urine biomarkers in SCD. This paper reviews the current contribution of biochemical markers associated with clinical manifestation and identification of sub-phenotypes in SCD. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.
引用
收藏
页码：24 / 31
页数：8
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