Connection between gut microbiome and the development of obesity

被引：58
|
作者：
Zhi, Cuiting [1 ,2 ]
Huang, Jingqing [1 ,2 ]
Wang, Jin [1 ,2 ]
Cao, Hua [3 ]
Bai, Yan [1 ]
Guo, Jiao [2 ]
Su, Zhengquan [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Guangdong Prov Univ, Engn Technol Res Ctr Nat Prod & Drugs, Guangdong Engn Res Ctr Nat Prod & New Drugs, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, SATCM,Level 3 Lab Lipid Metab SATCM,Inst Chinese, Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangdong TCM Key Lab Metabol Dis,Key Lab Modulat, Guangzhou 510006, Guangdong, Peoples R China
[3] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2019年 / 38卷 / 11期
基金：
美国国家科学基金会;
关键词：
Obesity; Gut microbiota; Fat accumulation; LPS; SCFAs; Strategies; DIET-INDUCED OBESITY; HIGH-FAT DIET; METABOLIC ENDOTOXEMIA; AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; APPETITE REGULATION; BARIATRIC SURGERY; PROPIONIC-ACID; RECEPTOR; INFLAMMATION;
D O I：
10.1007/s10096-019-03623-x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The potential role of the gut microbiota in various human diseases has attracted considerable attention worldwide. Here, we discuss the vital role of the intestinal microbiota in the development of obesity. First, we describe how the gut microbiota promotes fat accumulation. Additionally, a high-fat diet leads to structural instability among in the gut microbiota, further leading to an increase in endotoxins, which aggravates obesity. We then discuss how gut microbiota metabolites, including short-chain fatty acids and lipopolysaccharides, affect the host. Finally, we review several strategies for regulating the intestinal flora.
引用
收藏
页码：1987 / 1998
页数：12
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