Connection between gut microbiome and the development of obesity

被引：58
|
作者：
Zhi, Cuiting [1 ,2 ]
Huang, Jingqing [1 ,2 ]
Wang, Jin [1 ,2 ]
Cao, Hua [3 ]
Bai, Yan [1 ]
Guo, Jiao [2 ]
Su, Zhengquan [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Guangdong Prov Univ, Engn Technol Res Ctr Nat Prod & Drugs, Guangdong Engn Res Ctr Nat Prod & New Drugs, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, SATCM,Level 3 Lab Lipid Metab SATCM,Inst Chinese, Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangdong TCM Key Lab Metabol Dis,Key Lab Modulat, Guangzhou 510006, Guangdong, Peoples R China
[3] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2019年 / 38卷 / 11期
基金：
美国国家科学基金会;
关键词：
Obesity; Gut microbiota; Fat accumulation; LPS; SCFAs; Strategies; DIET-INDUCED OBESITY; HIGH-FAT DIET; METABOLIC ENDOTOXEMIA; AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; APPETITE REGULATION; BARIATRIC SURGERY; PROPIONIC-ACID; RECEPTOR; INFLAMMATION;
D O I：
10.1007/s10096-019-03623-x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The potential role of the gut microbiota in various human diseases has attracted considerable attention worldwide. Here, we discuss the vital role of the intestinal microbiota in the development of obesity. First, we describe how the gut microbiota promotes fat accumulation. Additionally, a high-fat diet leads to structural instability among in the gut microbiota, further leading to an increase in endotoxins, which aggravates obesity. We then discuss how gut microbiota metabolites, including short-chain fatty acids and lipopolysaccharides, affect the host. Finally, we review several strategies for regulating the intestinal flora.
引用
收藏
页码：1987 / 1998
页数：12
相关论文
共 50 条
  • [11] The gut microbiome in the fight against obesity: The potential of dietary factors
    Ahmad, Jamil
    Khan, Imran
    Zengin, Gokhan
    Mahomoodally, Mohamad Fawzi
    FASEB JOURNAL, 2023, 37 (11)
  • [12] Connection between gut microbiome and brain development in preterm infants
    Lu, Jing
    Claud, Erika C.
    DEVELOPMENTAL PSYCHOBIOLOGY, 2019, 61 (05) : 739 - 751
  • [13] Gut microbiota and obesity: lessons from the microbiome
    Cani, Patrice D.
    BRIEFINGS IN FUNCTIONAL GENOMICS, 2013, 12 (04) : 381 - 387
  • [14] Antibiotics, gut microbiome and obesity
    Leong, Karen S. W.
    Derraik, Jose G. B.
    Hofman, Paul L.
    Cutfield, Wayne S.
    CLINICAL ENDOCRINOLOGY, 2018, 88 (02) : 185 - 200
  • [15] Association between the gut and oral microbiome with obesity
    Benahmed, Asma Gasmi
    Gasmi, Amin
    Dosa, Alexandru
    Chirumbolo, Salvatore
    Mujawdiya, Pavan Kumar
    Aaseth, Jan
    Dadar, Maryam
    Bjorklund, Geir
    ANAEROBE, 2021, 70
  • [16] The links between gut microbiota and obesity and obesity related diseases
    Geng, Jiafeng
    Ni, Qingqiang
    Sun, Wei
    Li, Liangge
    Feng, Xiujing
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 147
  • [17] Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus
    Moreno-Indias, Isabel
    Cardona, Fernando
    Tinahones, Francisco J.
    Isabel Queipo-Ortuno, Maria
    FRONTIERS IN MICROBIOLOGY, 2014, 5
  • [18] Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease
    Mohammadkhah, Anica I.
    Simpson, Eoin B.
    Patterson, Stephanie G.
    Ferguson, Jane F.
    CHILDREN-BASEL, 2018, 5 (12):
  • [19] Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition
    Olsthoorn, Lisette
    Vreeken, Debby
    Kiliaan, Amanda J.
    FRONTIERS IN NEUROSCIENCE, 2021, 15
  • [20] The Gut Microbiome and Obesity
    John, George Kunnackal
    Mullin, Gerard E.
    CURRENT ONCOLOGY REPORTS, 2016, 18 (07)
12345