Adrenergic Receptor Polymorphisms in Heart Failure: what Can Genetics Explain?

被引：4
作者：
Pereira, Sabrina Bernardez [1 ]
Gava, Isabela Ambrosio [1 ]
Giro, Camila [1 ]
Mesquita, Evandro Tinoco [1 ]
机构：
[1] Univ Fed Fluminense, Rio De Janeiro, Brazil
来源：
ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2010年 / 94卷 / 06期
关键词：
BETA(2)-ADRENERGIC RECEPTOR; BETA(1)-ADRENERGIC RECEPTOR; BETA-2-ADRENOCEPTOR POLYMORPHISMS; THR164ILE POLYMORPHISM; DESENSITIZATION; ASSOCIATION; RESPONSES; RISK; BETA-1-ADRENOCEPTOR; SURVIVAL;
D O I：
10.1590/S0066-782X2010000600019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure (HF) is a complex disease, which involves several physiopathological mechanisms and different genetic polymorphisms. The adrenergic system is directly related to this pathology, as it participates in cardiovascular autoregulation and has a crucial role in the deterioration of cardiac function. The beta-blockers appeared as a great advance in cardiology for the treatment of HF; however, the drug response varies according to each patient, as several factors are associated, such as the genetic one. This review aims at assessing the genetic involvement in the development of HF, the drug response and the prognosis.
引用
收藏
页码：841 / 849
页数：9
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