Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women

被引：32

作者：

Baez, Sergio ^{[2
]}

Tsuchiya, Yasuo ^{[1
]}

Calvo, Alfonso ^{[2
]}

Pruyas, Martha ^{[3
]}

Nakamura, Kazutoshi

Kiyohara, Chikako ^{[4
]}

Oyama, Mari

Yamamoto, Masaharu ^{[5
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Community Prevent Med, Div Social & Environm Med,Chuo Ku, Niigata 9518510, Japan

[2] Hosp Dr Sotero del Rio, Dept Surg, Santiago, Chile

[3] Hosp Dr Sotero del Rio, Dept Anat Pathol, Santiago, Chile

[4] Kyushu Univ, Dept Prevent Med, Grad Sch Med Sci, Fukuoka 8128582, Japan

[5] Niigata Univ Hlth & Welf, Fac Hlth Sci, Niigata 9503198, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 03期

关键词：

Genetic risk factor; Gallbladder cancer; Gallstone; Genetic polymorphism; Apolipoprotein B; Cholesteryl ester transfer protein; TRANSFER PROTEIN GENE; APOLIPOPROTEIN-B; APO-B; POLYMORPHISM; DISEASE; LIPIDS; ATHEROSCLEROSIS; MUTAGENICITY; ASSOCIATION; POPULATION;

D O I：

10.3748/wjg.v16.i3.372

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC). METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffin block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman (R) SNP Genotyping Assays or Custom Taqman (R) SNP Genotyping Assays. RESULTS: The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR: 0.14, 95% CI: 0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR: 5.04, 95% CI: 1.43-17.8). CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs708272 polymorphisms may be related to the risk of developing GBC in Chilean women. (C) 2010 Baishideng. All rights reserved.

引用

页码：372 / 378

页数：7

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