Characterization of Low-Molecular-Weight PLA using HPLC

被引：39

作者：

Codari, Fabio ^{[2
]}

Moscatelli, Davide ^{[1
]}

Storti, Giuseppe ^{[1
]}

Morbidelli, Massimo ^{[2
]}

机构：

[1] Politecn Milan, Dipartimento Chim Mat & Ingn Chim Giulio Natta, I-20131 Milan, Italy

[2] ETH, Dept Chem & Appl Biosci, Inst Chem & Bioengn, CH-8093 Zurich, Switzerland

来源：

MACROMOLECULAR MATERIALS AND ENGINEERING | 2010年 / 295卷 / 01期

关键词：

characterization; high performance liquid chromatography (HPLC); lactic acid; PLA; polycondensation; RESORBABLE DEVICE DEGRADATION; AQUEOUS LACTIC-ACID; DRUG-RELEASE; POLY(LACTIC ACID); POLYLACTIC ACID; NEW-MODEL; IN-VITRO;

D O I：

10.1002/mame.200900172

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

HPLC is applied and assessed as an effective tool to investigate both the production of PLA by polycondensation and its corresponding degradation. A new HPLC calibration procedure, through which it is possible to fully characterize LMW PLA samples by determining the concentration of each individual oligomer, is developed. A comparison between HPLC, H-1 NMR spectroscopy and non-aqueous solution titration is also reported in order to confirm the reliability of the proposed method. Finally, the proposed analytical technique is applied to monitor the development of a polycondensation reaction performed at 150 degrees C and 133.3 mbar for 12 h.

引用

页码：58 / 66

页数：9

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