Synthesis of some new 2,6-bis pyridines functionalized with tetra-substituted pyrazole heterocycles

被引：4

作者：

Ali, Korany A. ^{[1
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt

来源：

ARKIVOC | 2014年

关键词：

beta-Keto esters; 2,6-bis pyridine- pyrazole; pyrazolo[4,3-d]pyridazine; DERIVATIVES; INHIBITORS;

D O I：

10.3998/ark.5550190.p008.775

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several new tetra-substituted pyrazoles attached to pyridine nucleus at positions 2 and 6 were synthesized from the reactions of 2,6-bis(ethoxycarbonyl-acetyl)pyridine (2) with different series of hydrazonoyl chlorides including; C-acetyl-N-aryl-hydrazonoyl chlorides (3a-c) and (C-ethoxycarbonyl)-N-aryl-hydrazonoyl chlorides (12a-c). The structures of the synthesized products were established on the basis of their elemental analysis and spectral data in addition to, the chemical behavior of the reaction products with hydrazine hydrate to afford the corresponding pyrazolo[4,3-d]pyridazine derivative.

引用

页码：399 / 407

页数：9

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