Role of liver-X-receptors in airway remodeling in mice with chronic allergic asthma

被引：3
|
作者：
Zhang, Jinmei [1 ]
Wu, Zhengcan [2 ]
Yu, Fenfang [1 ]
Ye, Liang [1 ]
Gu, Wei [1 ]
Tan, Yan [1 ]
Wang, Li [1 ]
Shi, Ying [1 ]
机构：
[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Resp Med, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Nanjing Hosp 1, Dept Radiol, Nanjing 210006, Jiangsu, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2021年 / 22卷 / 03期
关键词：
liver X receptors; asthma; airway inflammation; airway hyperresponsiveness; airway remodeling; NUCLEAR RECEPTORS; LIPID-METABOLISM; INFLAMMATION; EXPRESSION; IGE; ACTIVATION; MODEL; PPAR;
D O I：
10.3892/etm.2021.10352
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Liver X receptors (LXRs) exert anti-inflammatory effects in animal models of certain respiratory diseases. In the present study, a model of chronic airway remodeling was established in wild-type and LXR-deficient mice. Ovalbumin (OVA)-sensitized mice were chronically administered OVA via inhalation for 8 weeks. Prior to each stimulation, certain wild-type mice were treated with GW3965, which is a highly selective LXR agonist. The influence of LXRs on airway inflammation, airway hyperresponsiveness and airway remodeling was evaluated. LXRs were indicated to increase airway inflammation and airway hyperresponsiveness, as well as promote airway remodeling. These results suggest that inhibiting LXRs may be a potential method for the treatment of allergic asthma.
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页数：9
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