Role of liver-X-receptors in airway remodeling in mice with chronic allergic asthma

被引：3
|
作者：
Zhang, Jinmei [1 ]
Wu, Zhengcan [2 ]
Yu, Fenfang [1 ]
Ye, Liang [1 ]
Gu, Wei [1 ]
Tan, Yan [1 ]
Wang, Li [1 ]
Shi, Ying [1 ]
机构：
[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Resp Med, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Nanjing Hosp 1, Dept Radiol, Nanjing 210006, Jiangsu, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2021年 / 22卷 / 03期
关键词：
liver X receptors; asthma; airway inflammation; airway hyperresponsiveness; airway remodeling; NUCLEAR RECEPTORS; LIPID-METABOLISM; INFLAMMATION; EXPRESSION; IGE; ACTIVATION; MODEL; PPAR;
D O I：
10.3892/etm.2021.10352
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Liver X receptors (LXRs) exert anti-inflammatory effects in animal models of certain respiratory diseases. In the present study, a model of chronic airway remodeling was established in wild-type and LXR-deficient mice. Ovalbumin (OVA)-sensitized mice were chronically administered OVA via inhalation for 8 weeks. Prior to each stimulation, certain wild-type mice were treated with GW3965, which is a highly selective LXR agonist. The influence of LXRs on airway inflammation, airway hyperresponsiveness and airway remodeling was evaluated. LXRs were indicated to increase airway inflammation and airway hyperresponsiveness, as well as promote airway remodeling. These results suggest that inhibiting LXRs may be a potential method for the treatment of allergic asthma.
引用
收藏
页数：9
相关论文
共 50 条
  • [1] Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma
    Yao, Jing
    Jiang, Mingzi
    Zhang, Yunshi
    Liu, Xing
    Du, Qiang
    Feng, Ganzhu
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 32 : 24 - 31
  • [2] Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma
    Johnson, Jill R.
    Folestad, Erika
    Rowley, Jessica E.
    Noll, Elisa M.
    Walker, Simone A.
    Lloyd, Clare M.
    Rankin, Sara M.
    Pietras, Kristian
    Eriksson, Ulf
    Fuxe, Jonas
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2015, 308 (07) : L658 - L671
  • [3] Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity
    Ma, Wenxian
    Jin, Qiaoyan
    Guo, Haiqin
    Han, Xinpeng
    Xu, Lingbin
    Lu, Shemin
    Wu, Changgui
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [4] Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma
    Ge, Xiahui
    Bai, Chong
    Yang, Jianming
    Lou, Guoliang
    Li, Qiang
    Chen, Ruohua
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2013, 114 (07) : 1595 - 1605
  • [5] Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
    Tam, Anthony
    Osei, Emmanuel Twumasi
    Cheung, Chung Y.
    Hughes, Michael
    Yang, Chen X.
    McNagny, Kelly M.
    Dorscheid, Delbert R.
    Singhera, Gurpreet K.
    Hallstrand, Teal S.
    Warner, Stephanie
    Hogg, James C.
    Hackett, Tillie L.
    Lim, Chinten J.
    Sin, Don D.
    CELLS, 2022, 11 (19)
  • [6] Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma
    Zhang, Ning
    Xu, Jing
    Jiang, Congshan
    Lu, Shemin
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [7] Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model
    Jiang, Jun-xia
    Guan, Yan
    Shen, Hui-juan
    Jia, Yong-liang
    Shen, Jian
    Zhang, Lin-hui
    Liu, Qi
    Zhu, Yi-liang
    Xie, Qiang-min
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 868
  • [8] Inhibition of airway inflammation and remodeling by sitagliptin in murine chronic asthma
    Nader, Manar A.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 29 (02) : 761 - 769
  • [9] Cordycepin inhibits airway remodeling in a rat model of chronic asthma
    Fei, Xia
    Zhang, Xue
    Zhang, Guo-qing
    Bao, Wu-ping
    Zhang, Ying-ying
    Zhang, Min
    Zhou, Xin
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 88 : 335 - 341
  • [10] Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma
    Saraiva, Simone A.
    Silva, Adriana L.
    Xisto, Debora G.
    Abreu, Soraia C.
    Silva, Johnatas D.
    Silva, Pedro L.
    Teixeira, Tatiana P. F.
    Parra, Edwin R.
    Carvalho, Ana Laura N.
    Annoni, Raquel
    Mauad, Thais
    Capelozzi, Vera L.
    Silva, Patricia M. R.
    Martins, Marco A.
    Rocco, Patricia R. M.
    RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2011, 177 (02) : 141 - 148
12345