Pediatric Gliomas as Neurodevelopmental Disorders

被引：50

作者：

Baker, Suzanne J. ^{[1
]}

Ellison, David W. ^{[2
]}

Gutmann, David H. ^{[3
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Dev Neurobiol, 262 Danny Thomas Pl, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, 262 Danny Thomas Pl, Memphis, TN 38105 USA

[3] Washington Univ, Sch Med, Dept Neurol, Box 8111,660 S Euclid Ave, St Louis, MO 63110 USA

来源：

GLIA | 2016年 / 64卷 / 06期

关键词：

pilocytic astrocytoma; diffuse astrocytoma; glioblastoma; DIPG; pediatric glioma; MAPK PATHWAY ACTIVATION; NERVOUS-SYSTEM MYELINATION; INTRINSIC PONTINE GLIOMA; GROWTH-FACTOR RECEPTOR; HIGH-GRADE GLIOMAS; GENOMIC ANALYSIS; MOUSE MODEL; STEM-CELLS; K-RAS; PROGENITOR PROLIFERATION;

D O I：

10.1002/glia.22945

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain tumors represent the most common solid tumor of childhood, with gliomas comprising the largest fraction of these cancers. Several features distinguish them from their adult counterparts, including their natural history, causative genetic mutations, and brain locations. These unique properties suggest that the cellular and molecular etiologies that underlie their development and maintenance might be different from those that govern adult gliomagenesis and growth. In this review, we discuss the genetic basis for pediatric low-grade and high-grade glioma in the context of developmental neurobiology, and highlight the differences between histologically-similar tumors arising in children and adults.

引用

页码：879 / 895

页数：17

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