Protozoa traversal of the blood-brain barrier to invade the central nervous system

被引：30

作者：

Elsheikha, Hany M. ^{[1
]}

Khan, Naveed Ahmed ^{[1
]}

机构：

[1] Univ Nottingham, Sch Vet Med & Sci, Loughborough LE12 5RD, England

来源：

FEMS MICROBIOLOGY REVIEWS | 2010年 / 34卷 / 04期

关键词：

blood-brain barrier; cell adhesion; central nervous system; host-parasite interaction; neuropathogenesis; parasites; protozoa; MICROVASCULAR ENDOTHELIAL-CELLS; INTERCELLULAR-ADHESION MOLECULE-1; TOXOPLASMA-GONDII TACHYZOITES; HUMAN CEREBRAL MALARIA; AMEBA BALAMUTHIA-MANDRILLARIS; IN-VITRO MODEL; PLASMINOGEN-ACTIVATOR RECEPTOR; PLASMODIUM-FALCIPARUM MALARIA; BOVIS-INFECTED ERYTHROCYTES; NF-KAPPA-B;

D O I：

10.1111/j.1574-6976.2010.00215.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Neuropathogenic protozoa have evolved strategies to breach the blood-brain barrier and invade the central nervous system. These include transcellular, paracellular and the Trojan horse routes but the associated molecular mechanisms remain incompletely understood. Here, we summarize the current understanding of protozoa penetration across the blood-brain barrier, focusing on Plasmodium, Babesia, Trypanosoma, Toxoplasma, Acanthamoeba and Balamuthia. Advances in understanding the molecular pathways will offer opportunities for the rational development of novel therapeutic interventions.

引用

页码：532 / 553

页数：22

共 50 条

[1] Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System
Mustafa, Yasmin Mucuna
Meuren, Lana Monteiro
Antunes Coelho, Sharton Vinicius
de Arruda, Luciana Barros
FRONTIERS IN MICROBIOLOGY, 2019, 10
[2] Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier
Chang, YC
Stins, MF
McCaffery, MJ
Miller, GF
Pare, DR
Dam, T
Paul-Satyasee, M
Kim, KS
Kwon-Chung, KJ
INFECTION AND IMMUNITY, 2004, 72 (09) : 4985 - 4995
[3] Acanthamoeba produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system
Parisa N Mortazavi
Graham Goldsworthy
Ruth Kirk
Naveed A Khan
BMC Microbiology, 10
[4] Acanthamoeba produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system
Mortazavi, Parisa N.
Goldsworthy, Graham
Kirk, Ruth
Khan, Naveed A.
BMC MICROBIOLOGY, 2010, 10
[5] Role of the Blood-Brain Barrier in the Nutrition of the Central Nervous System
Campos-Bedolla, Patricia
Walter, Fruzsina R.
Veszelka, Szilvia
Deli, Maria A.
ARCHIVES OF MEDICAL RESEARCH, 2014, 45 (08) : 610 - 638
[6] Primary Central Nervous System Lymphoma and the Blood-Brain Barrier
Doolittle, Nancy D.
Fu, Rochelle
Ambady, Prakash
Neuwelt, Edward A.
BLOOD, 2016, 128 (22)
[7] Immunologic privilege in the central nervous system and the blood-brain barrier
Muldoon, Leslie L.
Alvarez, Jorge I.
Begley, David J.
Boado, Ruben J.
del Zoppo, Gregory J.
Doolittle, Nancy D.
Engelhardt, Britta
Hallenbeck, John M.
Lonser, Russell R.
Ohlfest, John R.
Prat, Alexandre
Scarpa, Maurizio
Smeyne, Richard J.
Drewes, Lester R.
Neuwelt, Edward A.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (01): : 13 - 21
[8] The blood-brain barrier and drug delivery in the central nervous system
Loch-Neckel, Gecioni
Koepp, Janice
REVISTA DE NEUROLOGIA, 2010, 51 (03) : 165 - 174
[9] Crossing the blood-brain barrier to central nervous system gene therapy
Lewis, MES
CLINICAL GENETICS, 1999, 56 (01) : 10 - 10
[10] The blood-brain barrier and nasal drug delivery to the central nervous system
Miyake, Marcel Menon
Bleier, Benjamin S.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2015, 29 (02) : 124 - 127

← 1 2 3 4 5 →