Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

被引：10

作者：

Kwan, Chak-Shing ^{[1
,2
]}

Wang, Tao ^{[1
,2
]}

Li, Min ^{[3
]}

Chan, Albert S. C. ^{[4
]}

Cai, Zongwei ^{[1
,2
]}

Leung, Ken Cham-Fai ^{[1
,2
]}

机构：

[1] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Baptist Univ, State Key Lab Environm & Biol Anal, Kowloon Tong, Kowloon, Hong Kong, Peoples R China

[3] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Kowloon, Hong Kong, Peoples R China

[4] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 89期

关键词：

CONSTRUCTION;

D O I：

10.1039/c9cc06200a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.

引用

页码：13426 / 13429

页数：4

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