Relationship between regional white matter hyperintensities and alpha oscillations in older adults

被引：11

作者：

Kumral, Deniz ^{[1
,2
,3
]}

Cesnaite, Elena ^{[1
]}

Beyer, Frauke ^{[1
,4
]}

Hofmann, Simon M. ^{[1
]}

Hensch, Tilman ^{[5
,6
,7
]}

Sander, Christian ^{[5
,6
]}

Hegerl, Ulrich ^{[8
]}

Haufe, Stefan ^{[9
,10
]}

Villringer, Arno ^{[1
,11
]}

Witte, A. Veronica ^{[1
,4
,11
]}

Nikulin, Vadim V. ^{[1
,10
,12
,13
]}

机构：

[1] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Stephan Str 1a, D-04103 Leipzig, Germany

[2] Univ Freiburg, Inst Psychol, Neuropsychol, Freiburg, Germany

[3] Univ Freiburg, Inst Psychol, Clin Psychol & Psychotherapy Unit, Freiburg, Germany

[4] Univ Leipzig, Subproject A1, CRC Obes Mech, Leipzig, Germany

[5] Univ Leipzig, Dept Psychiat & Psychotherapy, Med Ctr, Leipzig, Germany

[6] Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany

[7] IU Int Univ Appl Sci, Dept Psychol, Erfurt, Germany

[8] Goethe Univ Frankfurt, Dept Psychiat Psychosomat & Psychotherapy, Frankfurt, Germany

[9] Charite Univ Med Berlin, Berlin Ctr Adv Neuroimaging, Berlin, Germany

[10] Bernstein Ctr Computat Neurosci Berlin, Berlin, Germany

[11] Univ Med Ctr Leipzig, Clin Cognit Neurol, Leipzig, Germany

[12] HSE Univ, Ctr Cognit & Decis Making, Inst Cognit Neurosci, Moscow, Russia

[13] Charite Univ Med Berlin, Dept Neurol, Neurophys Grp, Berlin, Germany

来源：

NEUROBIOLOGY OF AGING | 2022年 / 112卷

关键词：

EEG; MRI; White matter hyperintensity; Aging; Alpha power; Resting-state; RANGE TEMPORAL CORRELATIONS; FUNCTIONAL CONNECTIVITY; VASCULAR-LESIONS; ALZHEIMERS-DISEASE; FREQUENCY BAND; EEG RHYTHMS; BRAIN; DYNAMICS; AGE; PERFORMANCE;

D O I：

10.1016/j.neurobiolaging.2021.10.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7-13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N = 907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and long-range temporal correlations. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMHs affecting a spatial organization of alpha sources. (C) 2021 The Author(s). Published by Elsevier Inc.

引用

页码：1 / 11

页数：11