SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

被引：297
|
作者：
Lei, Yuyang [1 ,2 ]
Zhang, Jiao [1 ,2 ,5 ]
Schiavon, Cara R. [8 ,9 ]
He, Ming [5 ]
Chen, Lili [2 ]
Shen, Hui [5 ,10 ]
Zhang, Yichi [5 ]
Yin, Qian [2 ]
Cho, Yoshitake [5 ]
Andrade, Leonardo [8 ]
Shadel, Gerald S. [9 ]
Hepokoski, Mark [6 ]
Lei, Ting [3 ]
Wang, Hongliang [4 ]
Zhang, Jin [7 ]
Yuan, Jason X. -J. [6 ]
Malhotra, Atul [6 ]
Manor, Uri [8 ]
Wang, Shengpeng [2 ]
Yuan, Zu-Yi [1 ]
Shyy, John Y-J. [5 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Cardiol, Xian, Peoples R China
[2] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Cardiovasc Res Ctr, Xian, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Pathol, Xian, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Pathogen Biol & Immunol, Xian, Shaanxi, Peoples R China
[5] Univ Calif San Diego, Dept Med, Cardiol, La Jolla, CA 92093 USA
[6] Univ Calif San Diego, Dept Med, Pulm Crit Care & Sleep Med, La Jolla, CA 92093 USA
[7] Univ Calif San Diego, Pharmacol, La Jolla, CA 92093 USA
[8] Salk Inst Biol Studies, Waitt Adv Biophoton Ctr, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
[9] Salk Inst Biol Studies, Mol & Cellular Biol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
[10] Yangzhou Univ, Affiliated Hosp, Cardiol, Yangzhou, Jiangsu, Peoples R China
来源：
CIRCULATION RESEARCH | 2021年 / 128卷 / 09期
基金：
中国国家自然科学基金;
关键词：
angiotensin-converting enzyme 2; endothelium; SARS-CoV-2; INFECTION;
D O I：
10.1161/CIRCRESAHA.121.318902
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1323 / 1326
页数：4
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