Herpes Simplex Virus Tegument ICP0 Is Capsid Associated, and Its E3 Ubiquitin Ligase Domain Is Important for Incorporation into Virions

被引：28

作者：

Delboy, Mark G. ^{[1
]}

Siekavizza-Robles, Carlos R. ^{[1
]}

Nicola, Anthony V. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Microbiol & Immunol, Richmond, VA 23298 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 03期

关键词：

EARLY PROTEIN VMW110; RING FINGER; DELETION MUTANTS; GENE-EXPRESSION; TYPE-1; MUTANT; VIRAL-DNA; HOST-CELL; PML; ACTIVATION; PHOSPHORYLATION;

D O I：

10.1128/JVI.02041-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus (HSV) immediate-early (IE) protein ICP0 is a multifunctional regulator of HSV infection. ICP0 that is present in the tegument layer has not been well characterized. Protein compositions of wild-type and ICP0 null virions were similar, suggesting that the absence of ICP0 does not grossly impair virion assembly. ICP0 has a RING finger domain with E3 ubiquitin ligase activity that is necessary for IE functions. Virions with mutations in this domain contained greatly reduced levels of tegument ICP0, suggesting that the domain influences the incorporation of ICP0. Virion ICP0 was resistant to removal by detergent and salt and was associated with capsids, features common to inner tegument proteins.

引用

页码：1637 / 1640

页数：4

共 60 条

[1] Epstein-Barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation-dependent process and phosphorylates the viral immediate-early protein BZLF1 [J].

Asai, Risa ;

Kato, Ai ;

Kato, Kentaro ;

Kanamori-Koyama, Mikiko ;

Sugimoto, Ken ;

Sairenji, Takeshi ;

Nishiyama, Yukihiro ;

Kawaguchi, Yasushi .

JOURNAL OF VIROLOGY, 2006, 80 (11) :5125-5134

[2] CHARACTERIZATION OF THE HERPES-SIMPLEX VIRION-ASSOCIATED FACTOR RESPONSIBLE FOR THE INDUCTION OF ALPHA-GENES [J].

BATTERSON, W ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1983, 46 (02) :371-377

[3] Herpes simplex virus type 1 immediate-early protein ICP0 and its isolated RING finger domain act as ubiquitin E3 ligases in vitro [J].

Boutell, C ;

Sadis, S ;

Everett, RD .

JOURNAL OF VIROLOGY, 2002, 76 (02) :841-850

[4] GENETIC STUDIES WITH HERPES-SIMPLEX VIRUS TYPE-1 - ISOLATION OF TEMPERATURE-SENSITIVE MUTANTS, THEIR ARRANGEMENT INTO COMPLEMENTATION GROUPS AND RECOMBINATION ANALYSIS LEADING TO A LINKAGE MAP [J].

BROWN, SM ;

RITCHIE, DA ;

SUBAKSHA.JH .

JOURNAL OF GENERAL VIROLOGY, 1973, 18 (MAR) :329-346

[5] Herpes simplex virus type 1 tegument proteins VP1/2 and UL37 are associated with intranuclear capsids [J].

Bucks, Michelle A. ;

O'Regan, Kevin J. ;

Murphy, Michael A. ;

Wills, John W. ;

Courtney, Richard J. .

VIROLOGY, 2007, 361 (02) :316-324

[6] ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase [J].

Burkham, J ;

Coen, DM ;

Weller, SK .

JOURNAL OF VIROLOGY, 1998, 72 (12) :10100-10107

[7] HERPES-SIMPLEX VIRUS TYPE-1 ICP0 REGULATES EXPRESSION OF IMMEDIATE-EARLY, EARLY, AND LATE GENES IN PRODUCTIVELY INFECTED-CELLS [J].

CAI, WZ ;

SCHAFFER, PA .

JOURNAL OF VIROLOGY, 1992, 66 (05) :2904-2915

[8] Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins [J].

Chelbi-Alix, MK ;

de Thé, H .

ONCOGENE, 1999, 18 (04) :935-941

[9] A HERPES-SIMPLEX VIRUS TYPE-1 MUTANT CONTAINING A DELETION WITHIN IMMEDIATE EARLY GENE-1 IS LATENCY-COMPETENT IN MICE [J].

CLEMENTS, GB ;

STOW, ND .

JOURNAL OF GENERAL VIROLOGY, 1989, 70 :2501-2506

[10] LOCALIZATION AND SYNTHESIS OF AN ANTIGENIC DETERMINANT OF HERPES-SIMPLEX VIRUS GLYCOPROTEIN-D THAT STIMULATES THE PRODUCTION OF NEUTRALIZING ANTIBODY [J].

COHEN, GH ;

DIETZSCHOLD, B ;

DELEON, MP ;

LONG, D ;

GOLUB, E ;

VARRICHIO, A ;

PEREIRA, L ;

EISENBERG, RJ .

JOURNAL OF VIROLOGY, 1984, 49 (01) :102-108

← 1 2 3 4 5 6 →