Metal-Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

被引：147

作者：

Prasad, Sahdeo ^{[1
]}

DuBourdieu, Dan ^{[2
]}

Srivastava, Ajay ^{[2
]}

Kumar, Prafulla ^{[2
]}

Lall, Rajiv ^{[2
]}

机构：

[1] Noble Pharma LLC, Res & Dev Lab, Menomonie, WI 54751 USA

[2] Vets Plus Inc, Res & Dev Lab, Menomonie, WI 54751 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 13期

关键词：

metals; curcumin; inflammation; oxidative stress; chronic diseases; CANCER-CELL-LINES; ANTIOXIDANT PROPERTIES; OXIDE NANOPARTICLES; GOLD NANOPARTICLES; ANTITUMOR-ACTIVITY; OXIDATIVE DAMAGE; ANTICANCER; STABILITY; INHIBITION; DELIVERY;

D O I：

10.3390/ijms22137094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin, an active component of the rhizome turmeric, has gained much attention as a plant-based compound with pleiotropic pharmacological properties. It possesses anti-inflammatory, antioxidant, hypoglycemic, antimicrobial, neuroprotective, and immunomodulatory activities. However, the health-promoting utility of curcumin is constrained due to its hydrophobic nature, water insolubility, poor bioavailability, rapid metabolism, and systemic elimination. Therefore, an innovative stride was taken, and complexes of metals with curcumin have been synthesized. Curcumin usually reacts with metals through the beta-diketone moiety to generate metal-curcumin complexes. It is well established that curcumin strongly chelates several metal ions, including boron, cobalt, copper, gallium, gadolinium, gold, lanthanum, manganese, nickel, iron, palladium, platinum, ruthenium, silver, vanadium, and zinc. In this review, the pharmacological, chemopreventive, and therapeutic activities of metal-curcumin complexes are discussed. Metal-curcumin complexes increase the solubility, cellular uptake, and bioavailability and improve the antioxidant, anti-inflammatory, antimicrobial, and antiviral effects of curcumin. Metal-curcumin complexes have also demonstrated efficacy against various chronic diseases, including cancer, arthritis, osteoporosis, and neurological disorders such as Alzheimer's disease. These biological activities of metal-curcumin complexes were associated with the modulation of inflammatory mediators, transcription factors, protein kinases, antiapoptotic proteins, lipid peroxidation, and antioxidant enzymes. In addition, metal-curcumin complexes have shown usefulness in biological imaging and radioimaging. The future use of metal-curcumin complexes may represent a new approach in the prevention and treatment of chronic diseases.

引用

页数：24

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