Identical lesion morphology in primary progressive and relapsing-remitting MS - an ultrahigh field MRI study

被引：39

作者：

Kuchling, Joseph ^{[1
]}

Ramien, Caren ^{[1
]}

Bozin, Ivan ^{[1
]}

Doerr, Jan ^{[3
]}

Harms, Lutz ^{[4
]}

Rosche, Berit ^{[4
]}

Niendorf, Thoralf ^{[5
,6
]}

Paul, Friedemann ^{[1
,3
,6
]}

Sinnecker, Tim ^{[1
,2
]}

Wuerfel, Jens ^{[4
,6
,7
,8
]}

机构：

[1] Charite, NeuroCure Clin Res Ctr, D-10117 Berlin, Germany

[2] Asklepios Fachklinikum Teupitz, Teupitz, Germany

[3] Charite, NeuroCure Clin Res Ctr, Clin & Expt MS Res Ctr, D-10117 Berlin, Germany

[4] Charite, Clin & Expt MS Res Ctr, D-10117 Berlin, Germany

[5] Charite, BUFF, Expt & Clin Res Ctr, D-10117 Berlin, Germany

[6] Max Delbrueck Ctr Mol Med, Berlin, Germany

[7] Max Delbrueck Ctr Mol Med, NeuroCure Clin Res Ctr BUFF, Berlin, Germany

[8] Univ Med Goettingen, Inst Neuroradiol, Gottingen, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 14期

关键词：

MRI; primary progressive multiple sclerosis; PPMS; relapsing-remitting multiple sclerosis; RRMS; ultrahigh field MRI; 7 T MRI; MULTIPLE-SCLEROSIS; CORTICAL-LESIONS;

D O I：

10.1177/1352458514531084

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.

引用

页码：1866 / 1871

页数：6

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