Constitutive gp130-JAK-STAT3 signaling induces a plasma cell malignancy featuring all characteristics of human myeloma - a novel in vivo myeloma model for a patient subgroup with STAT3 activation

被引：0
作者：
Steidle, S. [1 ]
Dechow, T. [1 ]
Goetze, K. [1 ]
Rudelius, M. [2 ]
Kratzat, S. [1 ]
Behnke, K. [1 ]
Pechloff, K. [3 ]
Bullinger, L. [4 ]
Fend, F. [5 ]
Mitova, N. [1 ]
Li, Z. [6 ]
Thaler, M. [3 ]
Bauer, J. [7 ]
Pietschmann, E. [1 ]
Albers, C. [1 ]
Grundler, R. [1 ]
Ruland, J. [3 ]
Peschel, C. [1 ]
Duyster, J. [8 ]
Rose-John, S. [9 ]
Bassermann, F. [1 ]
Keller, U. [1 ]
机构：
[1] Tech Univ Munich, Dept Med 3, D-80290 Munich, Germany
[2] Univ Wurzburg, Inst Pathol, Wurzburg, Germany
[3] Tech Univ Munich, Inst Clin Chem & Pathobiochem, D-80290 Munich, Germany
[4] Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany
[5] Univ Tubingen, Inst Pathol, Tubingen, Germany
[6] Tech Univ Munich, Dept Nucl Med, D-80290 Munich, Germany
[7] Tech Univ Munich, Inst Radiol, D-80290 Munich, Germany
[8] Univ Freiburg, Dept Med 1, D-79106 Freiburg, Germany
[9] Univ Kiel, Inst Biochem, Kiel, Germany
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2014年 / 37卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
V592
引用
收藏
页码：192 / 192
页数：1
相关论文
共 50 条
  • [41] A NOVEL SMALL MOLECULE EXHIBITS POTENT GROWTH SUPPRESSIVE ACTIVITY THROUGH THE INHIBITION OF CONSTITUTIVE JAK2/STAT3 SIGNALING IN HUMAN CANCER CELLS
    Lin, J.
    Lin, L.
    Hutzen, B.
    Ball, S.
    Zuo, M.
    Foust, E.
    DeAngelis, S.
    Wei, C. C.
    Peng, Z.
    Li, C.
    Fuchs, J.
    Li, P. K.
    Kulp, S.
    Lin, H. J.
    Ihnat, M. A.
    Lesinski, G. B.
    Hoyt, D.
    Termuhlen, A. M.
    Gross, T.
    ANNALS OF ONCOLOGY, 2009, 20 : 20 - 20
  • [42] Inhibition of cytokine receptor gp130 signaling in breast cancer cells results in decreased constitutive stat3 activation via inhibition of EGF receptor family members.
    Li, L
    Watson, L
    Merrell, M
    Selander, K
    Harris, KW
    JOURNAL OF INVESTIGATIVE MEDICINE, 2003, 51 : S286 - S286
  • [43] The combination of soluble IL-6 receptor and IL-6 induces tyrosine phosphorylation of GP130, Jak1, Jak2 and STAT3 in human platelets.
    Oda, A
    Nakahata, T
    Druker, BJ
    Ozaki, K
    Tsuji, K
    Yasukawa, K
    Kato, T
    Handa, M
    Ikeda, Y
    BLOOD, 1997, 90 (10) : 3018 - 3018
  • [44] Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance
    Shi, Lei
    Wang, Siqing
    Zangari, Maurizio
    Xu, Hongwei
    Cao, Thai M.
    Xu, Chunjiao
    Wu, Yong
    Xiao, Fang
    Liu, Yinghong
    Yang, Ye
    Salama, Mohamed
    Li, Guiyuan
    Tricot, Guido
    Zhan, Fenghuang
    ONCOTARGET, 2010, 1 (01) : 22 - 33
  • [45] Cardamonin, a Novel Blocker of STAT3 and Nuclear Factor-κB Activation, Suppresses Proliferation, Arrests Cell Cycle, and Potentiates Apoptosis In Human Multiple Myeloma Cells.
    Qin, You
    Sun, Chunyan
    Guo, Tao
    Wang, Yadan
    Zhang, Lu
    Chen, Lei
    She, Xiaomei
    Ai, Lisha
    Yan, Han
    Gregg, Nicholas Miller
    Fang, Jun
    Hu, Yu
    BLOOD, 2010, 116 (21) : 760 - 760
  • [46] Blockage of IL-6 mediated JAK2/STAT3 cell signaling pathway by sIL-6R effectively inhibited the growth of multiple myeloma cell.
    Park, Ju-Won
    Ahn, Kwang-Sung
    Kim, Young-Ju
    Bae, Eunkyung
    Lee, Yong-Yeol
    Yoon, Sung-Soo
    Kim, Inho
    Park, Seonyang
    Kim, Byoung-Kook
    BLOOD, 2006, 108 (11) : 360B - 360B
  • [47] The blockade of epidermal growth factor signaling in human cutaneous SCC cell lines suppresses the cell proliferation associated with the down-regulation of constitutive Stat3 activation
    Bito, T
    Ashida, M
    Budiyanto, A
    Ueda, M
    Ichihashi, M
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (01) : 223 - 223
  • [48] Proteasome inhibitor YSY01A abrogates constitutive STAT3 signaling via down-regulation of Gp130 and JAK2 in human A549 lung cancer cells (vol 8, 476, 2017)
    Huang, Wei
    Yuan, Xia
    Sun, Ting
    Fan, Shujie
    Wang, Jun
    Zhou, Quan
    Guo, Wei
    Ran, Fuxiang
    Ge, Zemei
    Yang, Huayu
    Li, Runtao
    Cui, Jingrong
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [49] Small molecule inhibitor of Stat3 induces antitumor cell effects in vitro and antitumor effects in vivo against human glioma or breast cancer model
    Yue, Peibin
    Lopez-Tapia, Francisco
    Tius, Marcus
    Turkson, James
    CANCER RESEARCH, 2014, 74 (19)
  • [50] CKS1B Mediates SKP2/p27Kip1-Independent Myeloma Cell Survival and Disease Progression through Activation of MEK/ERK and JAK/STAT3 Signaling Pathways
    Zhan, Fenghuang
    Shi, Lei
    Wang, Siqing
    Xu, Hongwei
    Cao, Thai M.
    Xu, Chunjiao
    Wu, Yong
    Zangari, Maurizio
    Li, Guiyuan
    Tricot, Guido J.
    BLOOD, 2009, 114 (22) : 57 - 57
12345