C-N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts

被引：205

作者：

Engl, Pascal S. ^{[1
]}

Haering, Andreas P. ^{[1
]}

Berger, Florian ^{[1
]}

Berger, Georg ^{[1
]}

Perez-Bitrian, Alberto ^{[1
]}

Ritter, Tobias ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 34期

基金：

瑞士国家科学基金会;

关键词：

H AMINATION; PALLADIUM; COPPER; ARYLATION; ARENES; AMIDATION; HETEROCYCLES; IMIDAZOLES; PRECURSORS; IMIDATION;

D O I：

10.1021/jacs.9b07323

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report diverse C-N cross-coupling reactions of aryl thianthrenium salts that are formed site-selectively by direct C-H functionalization. The scope of N-nucleophiles ranges from primary and secondary alkyl and aryl amines to various N-containing heterocycles, and the overall transformation is applicable to late-stage functionalization of complex, drug-like small molecules.

引用

页码：13346 / 13351

页数：6

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