ROS-MEDIATED ACTIVATION OF NF-κB AND FOXO DURING MUSCLE DISUSE

被引：110

作者：

Dodd, Stephen L. ^{[1
]}

Gagnon, Brittany J. ^{[1
]}

Senf, Sarah M. ^{[1
]}

Hain, Brian A. ^{[1
]}

Judge, Andrew R. ^{[1
]}

机构：

[1] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA

来源：

MUSCLE & NERVE | 2010年 / 41卷 / 01期

关键词：

oxidative stress; antioxidant; muscle wasting; cell signaling; atrophy; UBIQUITIN-CONJUGATING ACTIVITY; SKELETAL-MUSCLE; OXIDATIVE STRESS; TRANSCRIPTION FACTORS; RESVERATROL; INDUCTION; OVEREXPRESSION; EXPRESSION; PROTECTS; PATHWAY;

D O I：

10.1002/mus.21526

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined reactive oxygen species as upstream activators of nuclear factor kappa B; (NF-kappa B) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Call an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappa B and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy. Muscle Nerve 41: 110-113, 2010

引用

页码：110 / 113

页数：4

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