Early Seizures Are Predictive of Worse Health-Related Quality of Life at Follow-Up After Intracerebral Hemorrhage

被引:6
作者
Naidech, Andrew M. [1 ,2 ]
Weaver, Bradley [2 ]
Maas, Matthew [1 ]
Bleck, Thomas P. [1 ]
VanHaerents, Stephen [1 ]
Schuele, Stephan U. [1 ]
机构
[1] Northwestern Univ, Dept Neurol, Inst Publ Hlth & Med, Chicago, IL 60611 USA
[2] Northwestern Univ, Inst Publ Hlth & Med, Chicago, IL 60611 USA
基金
美国国家卫生研究院;
关键词
health-related quality of life; intracerebral hemorrhage; outcomes; seizures; seizure medications; NONCONVULSIVE SEIZURES; STATISTICAL-ANALYSIS; STROKE; OUTCOMES; SCALE; TRIALS; SHIFT; SCORE;
D O I
10.1097/CCM.0000000000004936
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
OBJECTIVES: Early seizures are a common complication of intracerebral hemorrhage, occurring in similar to 10% of patients. However, the independent effect of early seizures on patient outcomes, particularly health-related quality of life, is unclear. Without a potential benefit to patient outcomes, the widespread use (similar to 40%) of prophylactic seizure medications has no reasonable chance of improving patient outcomes. We tested the hypothesis that health-related quality of life at follow-up is different between patients with and without early seizures (and secondarily, with nonconvulsive status epilepticus) after intracerebral hemorrhage. DESIGN: Patients with intracerebral hemorrhage were enrolled in an observational cohort study that prospectively collected clinical data and health-related quality of life at follow-up. SETTING: Academic medical center. PATIENTS: One-hundred thirty-three patients whose health-related quality of life was assessed 3 months after intracerebral hemorrhage onset. MEASUREMENTS AND MAIN RESULTS: Health-related quality of life was obtained at 3 months after intracerebral hemorrhage onset. T Scores of health-related quality of life were modeled with multivariable linear models accounting for severity with the intracerebral hemorrhage Score and hematoma location. Health-related quality of life was measured with National Institutes of Health Patient Reported Outcomes Measurement Information System/Neuroquality of life, expressed in T Scores (U.S. normal 50 +/- 10). The modified Rankin Scale (a global measure) was a secondary outcome. There were 12 patients (9%) with early seizures. T Scores of health-related quality of life at follow-up were lower (worse) in patients with early seizure compared with patients without an early seizure (44 [32.75-51.85] vs 30.25 [18.9-39.15]; p = 0.04); results for other domains of health-related quality of life were similar. The association persisted in multivariable models. There was no association between early seizures and prophylactic seizure medications (p = 0.4). Results for patients with nonconvulsive status epilepticus were similar. There was no association between early seizures and the modified Rankin Scale at 3 months. CONCLUSIONS: Early seizures and nonconvulsive status epilepticus were associated with lower health-related quality of life at follow-up in survivors of intracerebral hemorrhage.
引用
收藏
页码:E578 / E584
页数:7
相关论文
共 28 条
  • [1] Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials
    Bath, Philip M. W.
    [J]. STROKE, 2007, 38 (06) : 1911 - 1915
  • [2] Statistical Analysis of the Primary Outcome in Acute Stroke Trials
    Bath, Philip M. W.
    Lees, Kennedy R.
    Schellinger, Peter D.
    Altman, Hernan
    Bland, Martin
    Hogg, Cheryl
    Howard, George
    Saver, Jeffrey L.
    [J]. STROKE, 2012, 43 (04) : 1171 - 1178
  • [3] Neuro-QOL Brief measures of health-related quality of life for clinical research in neurology
    Cella, D.
    Lai, J-S.
    Nowinski, C. J.
    Victorson, D.
    Peterman, A.
    Miller, D.
    Bethoux, F.
    Heinemann, A.
    Rubin, S.
    Cavazos, J. E.
    Reder, A. T.
    Sufit, R.
    Simuni, T.
    Holmes, G. L.
    Siderowf, A.
    Wojna, V.
    Bode, R.
    McKinney, N.
    Podrabsky, T.
    Wortman, K.
    Choi, S.
    Gershon, R.
    Rothrock, N.
    Moy, C.
    [J]. NEUROLOGY, 2012, 78 (23) : 1860 - 1867
  • [4] Nonconvulsive Seizures in Subarachnoid Hemorrhage Link Inflammation and Outcome
    Claassen, Jan
    Albers, David
    Schmidt, J. Michael
    De Marchis, Gian Marco
    Pugin, Deborah
    Falo, Christina Maria
    Mayer, Stephan A.
    Cremers, Serge
    Agarwal, Sachin
    Elkind, Mitchell S. V.
    Connolly, E. Sander
    Dukic, Vanja
    Hripcsak, George
    Badjatia, Neeraj
    [J]. ANNALS OF NEUROLOGY, 2014, 75 (05) : 771 - 781
  • [5] Nonconvulsive Seizures after Subarachnoid Hemorrhage: Multimodal Detection and Outcomes
    Claassen, Jan
    Perotte, Adler
    Albers, David
    Kleinberg, Samantha
    Schmidt, J. Michael
    Tu, Bin
    Badjatia, Neeraj
    Lantigua, Hector
    Hirsch, Lawrence J.
    Mayer, Stephan A.
    Connolly, E. Sander
    Hripcsak, George
    [J]. ANNALS OF NEUROLOGY, 2013, 74 (01) : 53 - 64
  • [6] Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome
    De Marchis, Gian Marco
    Pugin, Deborah
    Meyers, Emma
    Velasquez, Angela
    Suwatcharangkoon, Sureerat
    Park, Soojin
    Falo, M. Cristina
    Agarwal, Sachin
    Mayer, Stephan
    Schmidt, J. Michael
    Connolly, E. Sander
    Claassen, Jan
    [J]. NEUROLOGY, 2016, 86 (03) : 253 - 260
  • [7] Intracerebral hemorrhage location and outcome among INTERACT2 participants
    Delcourt, Candice
    Sato, Shoichiro
    Zhang, Shihong
    Sandset, Else Charlotte
    Zheng, Danni
    Chen, Xiaoying
    Hackett, Maree L.
    Arima, Hisatomi
    Hata, Jun
    Heeley, Emma
    Salman, Rustam Al-Shahi
    Robinson, Thompson
    Davies, Leo
    Lavados, Pablo M.
    Lindley, Richard I.
    Stapf, Christian
    Chalmers, John
    Anderson, Craig S.
    [J]. NEUROLOGY, 2017, 88 (15) : 1408 - 1414
  • [8] The CAVE Score for Predicting Late Seizures After Intracerebral Hemorrhage
    Haapaniemi, Elena
    Strbian, Daniel
    Rossi, Costanza
    Putaala, Jukka
    Sipi, Tuulia
    Mustanoja, Satu
    Sairanen, Tiina
    Curtze, Sami
    Satopaa, Jarno
    Roivainen, Reina
    Kaste, Markku
    Cordonnier, Charlotte
    Tatlisumak, Turgut
    Meretoja, Atte
    [J]. STROKE, 2014, 45 (07) : 1971 - 1976
  • [9] The ICH score - A simple, reliable grading scale for intracerebral hemorrhage
    Hemphill, JC
    Bonovich, DC
    Besmertis, L
    Manley, GT
    Johnston, SC
    [J]. STROKE, 2001, 32 (04) : 891 - 896
  • [10] PROMIS GH (Patient-Reported Outcomes Measurement Information System Global Health) Scale in Stroke A Validation Study
    Katzan, Irene L.
    Lapin, Brittany
    [J]. STROKE, 2018, 49 (01) : 147 - +