The potential value of the protein S-100B level as a criterion for hyperbaric oxygen treatment and prognostic marker in carbon monoxide poisoned patients

被引：12
作者：
Brvar, M
Mozina, H
Osredkar, J
Mozina, M
Brucan, A
Bunc, M
机构：
[1] Ljubljana Med Ctr, Sch Med, Inst Pathophysio, Clin Dept Cardiol, Ljubljana 1000, Slovenia
[2] Ljubljana Med Ctr, Poison Control Ctr, Ljubljana 1000, Slovenia
[3] Ljubljana Med Ctr, Ctr Intens Internal Med, Ljubljana 1000, Slovenia
[4] Ljubljana Med Ctr, Lab Biochem Anal, Ljubljana 1000, Slovenia
[5] Ljubljana Med Ctr, Dept Emergency Med, Ljubljana 1000, Slovenia
来源：
RESUSCITATION | 2003年 / 56卷 / 01期
关键词：
carbon monoxide; S-100B protein; hyperbaric oxygen; outcome; guidelines;
D O I：
10.1016/S0300-9572(02)00289-7
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Carbon monoxide (CO) poisoning resulting in diffuse tissue hypoxia. Cerebral hypoxia is a major cause of morbidity and mortality after CO poisoning. There are some clinical criteria that could help a physician to make a decision concerning the application of hyperbaric oxygenation therapy. However, it would be convenient to discover an objective biochemical serum marker that could help in the grade evaluation of CO poisoning and indication of therapy in CO-poisoned patients. We present two case reports where the established criteria for the CO poisoning were not optimum for the decision regarding therapy. It seems that the S-100B protein could be used as a biochemical marker of CO induced brain injury. S-100B values could perhaps help us to select patients for hyperbaric oxygen therapy and to predict the short and long term outcome. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：105 / 109
页数：5
相关论文
共 32 条
[1]   High serum S100B levels for trauma patients without head injuries [J].
Anderson, RE ;
Hansson, LO ;
Nilsson, O ;
Dijlai-Merzoug, R ;
Settergren, G .
NEUROSURGERY, 2001, 48 (06) :1255-1258
[2]   Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources [J].
Anderson, RE ;
Hansson, LO ;
Nilsson, O ;
Liska, J ;
Settergren, G ;
Vaage, J .
ANNALS OF THORACIC SURGERY, 2001, 71 (05) :1512-1517
[3]   Protein S-100B: A serum marker for ischemic and infectious injury of cerebral tissue [J].
Bertsch, T ;
Casarin, W ;
Kretschmar, M ;
Zimmer, W ;
Walter, S ;
Sommer, C ;
Muehlhauser, F ;
Ragoschke, A ;
Kuehl, S ;
Schmidt, R ;
Pohlmann-Eden, B ;
Nassabi, C ;
Nichterlein, T ;
Fassbender, K .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2001, 39 (04) :319-323
[4]  
Böttiger BW, 2001, CIRCULATION, V103, P2694
[5]   Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type [J].
Donato, R .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1999, 1450 (03) :191-231
[6]   Current concepts - Carbon monoxide poisoning [J].
Ernst, A ;
Zibrak, JD .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (22) :1603-1608
[7]   Serum neuron-specific enolase as early predictor of outcome after cardiac arrest [J].
Fogel, W ;
Krieger, D ;
Veith, M ;
Adams, HP ;
Hund, E ;
StorchHagenlocher, B ;
Buggle, F ;
Mathias, D ;
Hacke, W .
CRITICAL CARE MEDICINE, 1997, 25 (07) :1133-1138
[8]   On the release and half-life of S100B protein in the peripheral blood of melanoma patients [J].
Ghanem, G ;
Loir, B ;
Morandini, R ;
Sales, F ;
Lienard, D ;
Eggermont, A ;
Lejeune, F .
INTERNATIONAL JOURNAL OF CANCER, 2001, 94 (04) :586-590
[9]   A LONGITUDINAL-STUDY OF 100 CONSECUTIVE ADMISSIONS FOR CARBON-MONOXIDE POISONING TO THE ROYAL-ADELAIDE-HOSPITAL [J].
GORMAN, DF ;
CLAYTON, D ;
GILLIGAN, JE ;
WEBB, RK .
ANAESTHESIA AND INTENSIVE CARE, 1992, 20 (03) :311-316
[10]  
HAIMOTO H, 1987, LAB INVEST, V57, P489
1234