A functional DNA methylation system in the pea aphid, Acyrthosiphon pisum

被引：106
|
作者：
Walsh, T. K. [1 ]
Brisson, J. A. [2 ]
Robertson, H. M. [3 ]
Gordon, K. [4 ]
Jaubert-Possamai, S. [5 ]
Tagu, D. [5 ]
Edwards, O. R. [1 ]
机构：
[1] CELS, CSIRO Entomol, Floreat Pk, WA 6914, Australia
[2] Univ So Calif, Los Angeles, CA USA
[3] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA
[4] CSIRO Entomol, Canberra, ACT, Australia
[5] INRA, UMR1099, BiO3p, Le Rheu, France
来源：
INSECT MOLECULAR BIOLOGY | 2010年 / 19卷
关键词：
DNA methylation; methylcytosine; pea aphid; phenotypic plasticity; epigenetic; GENE-BODY METHYLATION; INSECTICIDE RESISTANCE; WING POLYPHENISM; CPG METHYLATION; ESTERASE; METHYLTRANSFERASE; IDENTIFICATION; EXPRESSION; DIFFERENTIATION; INVERTEBRATES;
D O I：
10.1111/j.1365-2583.2009.00974.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Methylation of cytosine is one of the main epigenetic mechanisms involved in controlling gene expression. Here we show that the pea aphid (Acyrthosiphon pisum) genome possesses homologues to all the DNA methyltransferases found in vertebrates, and that 0.69% (+/- 0.25%) of all cytosines are methylated. Identified methylation sites are predominantly restricted to the coding sequence of genes at CpG sites. We identify twelve methylated genes, including genes that interact with juvenile hormone, a key endocrine signal in insects. Bioinformatic prediction using CpG ratios for all predicted genes suggest that a large proportion of genes are methylated within the pea aphid.
引用
收藏
页码：215 / 228
页数：14
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