Phytotherapy in the management of denture stomatitis: A systematic review and meta-analysis of randomized controlled trials

被引:4
作者
Shui, Yusen [1 ]
Li, Jingya [1 ]
Lyu, Xiaoying [1 ]
Wang, Yan [1 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, Dept Pediat Dent, State Key Lab Oral Dis,Natl Clin Res Ctr Oral Dis, 14 3rd Sect,S Renmin Rd, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
Candida albicans; denture stomatitis; herbal medicine; phytotherapy; SODIUM-HYPOCHLORITE; RICINUS-COMMUNIS; ANTIFUNGAL ACTIVITY; ORAL CANDIDOSIS; PUNICA-GRANATUM; IN-VITRO; EFFICACY; COMBINATION; MOUTHWASH; AMPHOTERICIN;
D O I
10.1002/ptr.7073
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Medicinal plant extracts are commonly applied for infectious diseases and are perceived as alternatives to conventional antimicrobial agents. We aimed to confirm the efficacy of phytotherapy for denture stomatitis compared with conventional therapies and placebo. A comprehensive literature search was conducted in Pubmed, Embase, Cochrane Library (CENTRAL), Scopus, and Web of Science, in addition to manual searching. Randomized controlled trials (RCTs) published in English, and studying the treatment of denture stomatitis with herbal medicines, were included. The outcome measures included the relief of clinical signs, reduced Candida colony counts, adverse effects, and patient satisfaction. Nineteen RCTs were included for a systematic review based on selection criteria. Two of them were analyzed using a random-effects model. There was no difference in the relief of clinical signs (odds ratio (OR) = 0.96; 95% confidence interval (CI): 0.43-2.15) and microbiological improvement (OR = 1.74; 95% CI: 0.55-5.45) between propolis and miconazole. Most of the included studies showed that phytomedicines had fewer side effects and more patient satisfaction than antifungals or disinfectants. However, further RCTs with more standardly prepared herbal formulations are required to verify the clinical efficacy of phytotherapy as an alternative or adjunctive therapy for denture stomatitis.
引用
收藏
页码:4111 / 4126
页数:16
相关论文
共 71 条
[1]  
Abdollahzadeh Sh, 2011, J Dent (Tehran), V8, P1
[2]   Miconazole gel compared with Zataria multiflora Boiss. gel in the treatment of denture stomatitis [J].
Amanlou, Massoud ;
Beitollahi, Jalil Momen ;
Abdollahzadehz, Shervin ;
Tohidast-Ekrad, Zahra .
PHYTOTHERAPY RESEARCH, 2006, 20 (11) :966-969
[3]  
[Anonymous], 2008, DENT MANAGEMENT MEDI
[4]   The effects of three disinfection protocols on Candida spp., denture stomatitis, and bio film: A parallel group randomized controlled trial [J].
Badaro, Mauricio Malheiros ;
Bueno, Frank Lucarini ;
Arnez, Raissa Macaroff ;
Oliveira, Viviane de Cassia ;
Macedo, Ana Paula ;
de Souza, Raphael Freitas ;
Oliveira Paranhos, Helena de Freitas ;
Silva-Lovato, Claudia Helena .
JOURNAL OF PROSTHETIC DENTISTRY, 2020, 124 (06) :690-698
[5]   Clinical trial for evaluation of Ricinus communis and sodium hypochlorite as denture cleanser [J].
Badaro, Mauricio Malheiros ;
Salles, Marcela Moreira ;
Fagundes Leite, Vanessa Maria ;
Ferraz de Arruda, Carolina Noronha ;
Oliveira, Viviane de Cassia ;
do Nascimento, Cassia ;
de Souza, Raphael Freitas ;
de Oliveira Paranhos, Helena de Freitas ;
Silva-Lovato, Claudia Helena .
JOURNAL OF APPLIED ORAL SCIENCE, 2017, 25 (03) :324-334
[6]   Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis [J].
Bakhshi, Mahin ;
Taheri, Jamileh-Bigom ;
Shabestari, Samira Basir ;
Tanik, Anett ;
Pahlevan, Roozbeh .
GERODONTOLOGY, 2012, 29 (02) :E680-E684
[7]   Drug discovery from medicinal plants [J].
Balunas, MJ ;
Kinghorn, AD .
LIFE SCIENCES, 2005, 78 (05) :431-441
[8]  
Banting D W, 2001, Spec Care Dentist, V21, P4, DOI 10.1111/j.1754-4505.2001.tb00216.x
[9]  
Bassiri-Jahromi S, 2018, IRAN J MED SCI, V43, P296
[10]   COMPARATIVE TRIAL OF FLUCONAZOLE AND AMPHOTERICIN IN THE TREATMENT OF DENTURE STOMATITIS [J].
BISSELL, V ;
FELIX, DH ;
WRAY, D .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1993, 76 (01) :35-39