Targeting vascular (endothelial) dysfunction

被引：409

作者：

Daiber, Andreas ^{[1
,2
]}

Steven, Sebastian ^{[1
,3
]}

Weber, Alina ^{[1
]}

Shuvaev, Vladimir V. ^{[4
]}

Muzykantov, Vladimir R. ^{[4
]}

Laher, Ismail ^{[5
]}

Li, Huige ^{[2
,6
]}

Lamas, Santiago ^{[7
]}

Muenzel, Thomas ^{[1
,2
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Med Ctr, Ctr Cardiol, Mainz, Germany

[2] German Ctr Cardiovascular Res DZHK, Partner Site Rhine Main, Mainz, Germany

[3] Johannes Gutenberg Univ Mainz, Ctr Thrombosis & Hemostasis, Med Ctr, Mainz, Germany

[4] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

[5] Univ British Columbia, Dept Pharmacol & Therapeut, Fac Med, Vancouver, BC, Canada

[6] Johannes Gutenberg Univ Mainz, Dept Pharmacol, Med Ctr, Mainz, Germany

[7] Ctr Biol Mol Severo Ochoa CSIC UAM, Dept Cell Biol & Immunol, Madrid, Spain

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2017年 / 174卷 / 12期

关键词：

NITRIC-OXIDE SYNTHASE; FLOW-MEDIATED DILATION; PULSE-WAVE-VELOCITY; SOLUBLE GUANYLATE-CYCLASE; PULMONARY ARTERIAL-HYPERTENSION; ALLEVIATES OXIDATIVE STRESS; TERM CARDIOVASCULAR EVENTS; VITAMIN-E SUPPLEMENTATION; C-REACTIVE PROTEIN; CORONARY-ARTERY;

D O I：

10.1111/bph.13517

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiovascular diseases are major contributors to global deaths and disability-adjusted life years, with hypertension a significant risk factor for all causes of death. The endothelium that lines the inner wall of the vasculature regulates essential haemostatic functions, such as vascular tone, circulation of blood cells, inflammation and platelet activity. Endothelial dysfunction is an early predictor of atherosclerosis and future cardiovascular events. We review the prognostic value of obtaining measurements of endothelial function, the clinical techniques for its determination, the mechanisms leading to endothelial dysfunction and the therapeutic treatment of endothelial dysfunction. Since vascular oxidative stress and inflammation are major determinants of endothelial function, we have also addressed current antioxidant and anti-inflammatory therapies. In the light of recent data that dispute the prognostic value of endothelial function in healthy human cohorts, we also discuss alternative diagnostic parameters such as vascular stiffness index and intima/media thickness ratio. We also suggest that assessing vascular function, including that of smooth muscle and even perivascular adipose tissue, may be an appropriate parameter for clinical investigations.

引用

页码：1591 / 1619

页数：29

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