Recent Advances in pH- or/and Photo-Responsive Nanovehicles

被引：34
作者：
Shin, Yuseon [1 ,2 ]
Husni, Patihul [1 ,2 ]
Kang, Kioh [1 ,2 ]
Lee, Dayoon [1 ,2 ]
Lee, Sehwa [1 ,2 ]
Lee, Eunseong [3 ]
Youn, Yuseok [4 ]
Oh, Kyungtaek [1 ,2 ]
机构：
[1] Chung Ang Univ, Dept Global Innovat Drugs, Grad Sch, 221 Heukseok Dong, Seoul 06974, South Korea
[2] Chung Ang Univ, Coll Pharm, 221 Heukseok Dong, Seoul 06974, South Korea
[3] Catholic Univ Korea, Div Biotechnol, Bucheon 14662, South Korea
[4] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea
来源：
PHARMACEUTICS | 2021年 / 13卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
chemotherapy; nanovehicles; light; pH; stimuli; photothermal; photodynamic; protonation; acid-labile bond; DRUG-DELIVERY SYSTEMS; MESOPOROUS SILICA NANOPARTICLES; CHEMO-PHOTOTHERMAL THERAPY; BLOCK-COPOLYMER MICELLES; FLOWER-LIKE MICELLES; PLGA-PEG-PLGA; PHOTODYNAMIC THERAPY; BIOMEDICAL APPLICATIONS; INTRACELLULAR DELIVERY; SENSITIVE MICELLES;
D O I：
10.3390/pharmaceutics13050725
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.
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页数：32
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