Metabolite reanalysis revealed potential biomarkers for COVID-19: a potential link with immune response

被引：6
作者：
Chen, Xin [1 ,4 ]
Gu, Mingli [2 ]
Li, Tengda [3 ]
Sun, Yi [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Lab Med, Sch Med, Shanghai 200080, Peoples R China
[2] Navy Mil Med Univ, Changhai Hosp, Dept Lab Diag, Shanghai 200433, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Expt Hematol, Natl Clin Res Ctr Blood Dis, Inst Hematol & Blood Dis Hosp, Tianjin 300020, Peoples R China
[4] Princeton High Sch, Princeton, NJ 08540 USA
来源：
FUTURE MICROBIOLOGY | 2021年 / 16卷 / 08期
关键词：
biomarkers; COVID-19; immune response; metabolomic profiling; METABOANALYST; METABOLOMICS; SERVER; ACID;
D O I：
10.2217/fmb-2021-0047
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: To understand the pathological progress of COVID-19 and to explore the potential biomarkers. Background: The COVID-19 pandemic is ongoing. There is metabolomics research about COVID-19 indicating the rich information of metabolomics is worthy of further data mining. Methods: We applied bioinformatics technology to reanalyze the published metabolomics data of COVID-19. Results: Benzoate, beta-alanine and 4-chlorobenzoic acid were first reported to be used as potential biomarkers to distinguish COVID-19 patients from healthy individuals; taurochenodeoxycholic acid 3-sulfate, glucuronate and N,N,N-trimethyl-alanylproline betaine TMAP are the top classifiers in the receiver operating characteristic curve of COVID-severe and COVID-nonsevere patients. Conclusion: These unique metabolites suggest an underlying immunoregulatory treatment strategy for COVID-19.
引用
收藏
页码：577 / 588
页数：12
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