Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

被引：49
作者：
Horiuchi, Kumiko
Shiota, Sumiko
Kuroda, Teruo
Hatano, Tsutomu
Yoshida, Takashi
Tsuchiya, Tomofusa [1 ]
机构：
[1] Okayama Univ, Dept Mol Microbiol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan
[2] Okayama Univ, Dept Pharmacognosy, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan
[3] Shujitsu Univ, Lab Pathogen Microbiol, Sch Pharm, Okayama 7038516, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 02期
关键词：
carnosol; carnosic acid; aminoglycoside; vancomycin-resistant enterococci (VRE);
D O I：
10.1248/bpb.30.287
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.
引用
收藏
页码：287 / 290
页数：4
相关论文
共 31 条
  • [1] The use of linezolid in the treatment of vancomycin-resistant enterococcal septicaemia in two patients with burn injuries
    Atkins, JL
    Hidvegi, N
    Teare, L
    Dziewulski, P
    [J]. BURNS, 2002, 28 (02) : 185 - 188
  • [2] National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004
    Cardo, D
    Horan, T
    Andrus, M
    Dembinski, M
    Edwards, J
    Peavy, G
    Tolson, J
    Wagner, D
    [J]. AMERICAN JOURNAL OF INFECTION CONTROL, 2004, 32 (08) : 470 - 485
  • [3] Centers for Disease Control and Prevention (CDC), 1993, MMWR Morb Mortal Wkly Rep, V42, P597
  • [4] Vancomycin-resistant enterococci
    Cetinkaya, Y
    Falk, P
    Mayhall, CG
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (04) : 686 - +
  • [5] The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli
    Chollet, R
    Chevalier, J
    Bryskier, A
    Pagés, JM
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (09) : 3621 - 3624
  • [6] Remarktable synergies between baicalein and tetracycline, and baicalein and β-lactams against methicillin-resistant Staphylococcus aureus
    Fujita, M
    Shiota, S
    Kuroda, T
    Hatano, T
    Yoshida, T
    Mizushima, T
    Tsuchiya, T
    [J]. MICROBIOLOGY AND IMMUNOLOGY, 2005, 49 (04) : 391 - 396
  • [7] HUANG MT, 1994, CANCER RES, V54, P701
  • [8] Effect of garlic on vancomycin-resistant enterococci
    Jonkers, D
    Sluimer, J
    Stobberingh, E
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (12) : 3045 - 3045
  • [9] Kariyama R, 2001, Nihon Rinsho, V59, P733
  • [10] Occurrence and spread of antibiotic resistances in Enterococcus faecium
    Klare, I
    Konstabel, C
    Badstübner, D
    Werner, G
    Witte, W
    [J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2003, 88 (2-3) : 269 - 290
1234