Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

被引：50
作者：
Horiuchi, Kumiko
Shiota, Sumiko
Kuroda, Teruo
Hatano, Tsutomu
Yoshida, Takashi
Tsuchiya, Tomofusa [1 ]
机构：
[1] Okayama Univ, Dept Mol Microbiol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan
[2] Okayama Univ, Dept Pharmacognosy, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan
[3] Shujitsu Univ, Lab Pathogen Microbiol, Sch Pharm, Okayama 7038516, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 02期
关键词：
carnosol; carnosic acid; aminoglycoside; vancomycin-resistant enterococci (VRE);
D O I：
10.1248/bpb.30.287
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.
引用
收藏
页码：287 / 290
页数：4
相关论文
共 31 条
[1]   The use of linezolid in the treatment of vancomycin-resistant enterococcal septicaemia in two patients with burn injuries [J].
Atkins, JL ;
Hidvegi, N ;
Teare, L ;
Dziewulski, P .
BURNS, 2002, 28 (02) :185-188
[2]   National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004 [J].
Cardo, D ;
Horan, T ;
Andrus, M ;
Dembinski, M ;
Edwards, J ;
Peavy, G ;
Tolson, J ;
Wagner, D .
AMERICAN JOURNAL OF INFECTION CONTROL, 2004, 32 (08) :470-485
[3]  
Centers for Disease Control and Prevention (CDC), 1993, MMWR Morb Mortal Wkly Rep, V42, P597
[4]   Vancomycin-resistant enterococci [J].
Cetinkaya, Y ;
Falk, P ;
Mayhall, CG .
CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (04) :686-+
[5]   The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli [J].
Chollet, R ;
Chevalier, J ;
Bryskier, A ;
Pagés, JM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (09) :3621-3624
[6]   Remarktable synergies between baicalein and tetracycline, and baicalein and β-lactams against methicillin-resistant Staphylococcus aureus [J].
Fujita, M ;
Shiota, S ;
Kuroda, T ;
Hatano, T ;
Yoshida, T ;
Mizushima, T ;
Tsuchiya, T .
MICROBIOLOGY AND IMMUNOLOGY, 2005, 49 (04) :391-396
[7]  
HUANG MT, 1994, CANCER RES, V54, P701
[8]   Effect of garlic on vancomycin-resistant enterococci [J].
Jonkers, D ;
Sluimer, J ;
Stobberingh, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (12) :3045-3045
[9]  
Kariyama R, 2001, Nihon Rinsho, V59, P733
[10]   Occurrence and spread of antibiotic resistances in Enterococcus faecium [J].
Klare, I ;
Konstabel, C ;
Badstübner, D ;
Werner, G ;
Witte, W .
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2003, 88 (2-3) :269-290
1234