Effectiveness of Proton Beam Therapy on Liver Metastases of Esophageal Cancer: Report of a Case

被引：6

作者：

Muroi, Hiroto ^{[1
,2
]}

Nakajima, Masanobu ^{[1
,2
]}

Satomura, Hitoshi ^{[1
,2
]}

Takahashi, Masakazu ^{[1
,2
]}

Domeki, Yasushi ^{[2
]}

Murakami, Masao ^{[1
,3
]}

Nakamura, Tatsuya ^{[4
]}

Takada, Akinori ^{[4
]}

Kato, Hiroyuki ^{[1
,2
]}

机构：

[1] Dept Surg 1, Cambridge, MA USA

[2] Dept Radiol, Cambridge, MA USA

[3] Dokkyo Med Univ, Mibu, Tochigi 3210293, Japan

[4] Southern Tohoku Proton Therapy Ctr, Koriyama, Fukushima 9638563, Japan

来源：

INTERNATIONAL SURGERY | 2015年 / 100卷 / 01期

关键词：

proton beam therapy; esophageal cancer; liver metastasis; HEPATOCELLULAR-CARCINOMA;

D O I：

10.9738/INTSURG-D-13-00188.1

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A 53-year-old man with multiple liver metastasis of esophageal cancer underwent four courses of chemotherapy. After four courses of chemotherapy, positron emission tomography showed progressive disease. Because it was difficult to control the cancer only by chemotherapy, we performed proton beam therapy (PBT) combined with chemotherapy. The irradiated parts were the primary tumor, liver metastases (S2/S4/S6), and mediastinal lymph nodes. The primary tumor including the mediastinal lymph nodes and the S2/S4/S6 metastases received proton beam irradiation at a total dose of 68.2 Gy in 31 fractions and 66.0 Gy in 30 fractions, respectively, according to tumor location. This resulted in a complete response as shown by positron emission tomography. In our experience, PBT exerted a curative effect on liver metastases of esophageal cancer. It is thought that PBT may be effective in the treatment of esophageal cancer. This is the first report about PBT for liver metastases of esophageal cancer.

引用

页码：180 / 184

页数：5

共 9 条

[1] The Safety and Efficacy of High-Dose Proton Beam Radiotherapy for Hepatocellular Carcinoma: A Phase 2 Prospective Trial [J].

Bush, David A. ;

Kayali, Zeid ;

Grove, Roger ;

Slater, Jerry D. .

CANCER, 2011, 117 (13) :3053-3059

[2] Proton beam therapy for hepatocellular carcinoma: A retrospective review of 162 patients [J].

Chiba, T ;

Tokuuye, K ;

Matsuzaki, Y ;

Sugahara, S ;

Chuganji, Y ;

Kagei, K ;

Shoda, J ;

Hata, M ;

Abei, M ;

Igaki, H ;

Tanaka, N ;

Akine, Y .

CLINICAL CANCER RESEARCH, 2005, 11 (10) :3799-3805

[3]

Hata M, 2007, INT J RADIAT ONCOL, V69, P805, DOI 10.1016/j.ijrobp.2007.04.016

[4] Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis [J].

Hata, Masaharu ;

Tokuuye, Koichi ;

Sugahara, Shinji ;

Fukumitsu, Nobuyoshi ;

Hashimoto, Takayuki ;

Ohnishi, Kayoko ;

Nemoto, Keiko ;

Ohara, Kiyoshi ;

Matsuzaki, Yasushi ;

Akine, Yasuyuki .

STRAHLENTHERAPIE UND ONKOLOGIE, 2006, 182 (12) :713-720

[5]

Ikeda Y, 2003, HEPATO-GASTROENTEROL, V50, P532

[6] Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma [J].

Kawashima, M ;

Furuse, J ;

Nishio, T ;

Konishi, M ;

Ishii, H ;

Kinoshita, T ;

Nagase, M ;

Nihei, KI ;

Ogino, T .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (09) :1839-1846

[7] Evaluation of Liver Function After Proton Beam Therapy for Hepatocellular Carcinoma [J].

Mizumoto, Masashi ;

Okumura, Toshiyuki ;

Hashimoto, Takayuki ;

Fukuda, Kuniaki ;

Oshiro, Yoshiko ;

Fukumitsu, Nobuyoshi ;

Abei, Masato ;

Kawaguchi, Atsushi ;

Hayashi, Yasutaka ;

Ohkawa, Ayako ;

Hashii, Haruko ;

Kanemoto, Ayae ;

Moritake, Takashi ;

Tohno, Eriko ;

Tsuboi, Koji ;

Sakae, Takeji ;

Sakurai, Hideyuki .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (03) :E529-E535

[8] Results of Proton Beam Therapy without Concurrent Chemotherapy for Patients with Unresectable Stage III Non-small Cell Lung Cancer [J].

Oshiro, Yoshiko ;

Mizumoto, Masashi ;

Okumura, Toshiyuki ;

Hashimoto, Takayuki ;

Fukumitsu, Nobuyoshi ;

Ohkawa, Ayako ;

Kanemoto, Ayae ;

Hashii, Haruko ;

Ohno, Toshiki ;

Sakae, Takeji ;

Tsuboi, Koji ;

Sakurai, Hideyuki .

JOURNAL OF THORACIC ONCOLOGY, 2012, 7 (02) :370-375

[9] Global cancer statistics, 2002 [J].

Parkin, DM ;

Bray, F ;

Ferlay, J ;

Pisani, P .

CA-A CANCER JOURNAL FOR CLINICIANS, 2005, 55 (02) :74-108

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