Secondary Brain Injury by Oxidative Stress After Cerebral Hemorrhage: Recent Advances

被引：22
作者：
Shao, Linqian [1 ]
Chen, Sichao [1 ]
Ma, Li [1 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Neurosurg, Sch Med, Hangzhou, Peoples R China
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷
关键词：
cerebral hemorrhage; oxidative stress; research progress; Nrf2; heme oxygenase; SPONTANEOUS INTRACEREBRAL HEMORRHAGE; SUPEROXIDE-DISMUTASE; HEME OXYGENASE; MITOCHONDRIAL DYSFUNCTION; MATRIX METALLOPROTEINASES; INFLAMMATORY REACTION; VASCULAR DYSFUNCTION; RADICAL SCAVENGER; NEURONAL DEATH; ACTIVATION;
D O I：
10.3389/fncel.2022.853589
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intracerebral hemorrhage (ICH) is a clinical syndrome in which blood accumulates in the brain parenchyma because of a nontraumatic rupture of a blood vessel. Because of its high morbidity and mortality rate and the lack of effective therapy, the treatment of ICH has become a hot research topic. Meanwhile, Oxidative stress is one of the main causes of secondary brain injury(SBI) after ICH. Therefore, there is a need for an in-depth study of oxidative stress after ICH. This review will discuss the pathway and effects of oxidative stress after ICH and its relationship with inflammation and autophagy, as well as the current antioxidant therapy for ICH with a view to deriving better therapeutic tools or targets for ICH.
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页数：13
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