A facile method for nucleophilic aromatic substitution of cyclic amine

被引：28

作者：

Kidwai, M ^{[1
]}

Sapra, P ^{[1
]}

Dave, B ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 24期

关键词：

microwave irradiation; basic alumina; nucleophillic aromatic substitution; piperidine morpholine;

D O I：

10.1080/00397910008087076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The expeditious solventless nucleophilic aromatic substitution using microwaves is described. A non-conventional synthetic procedure has been developed where basic alumina has been used as energy transfer medium under Microwave Irradiation (MWI). The results were compared with those obtained by the classical method. This rapid and environmentally benign method avoids the use of excess solvents and toxic bases usually employed in the process make this procedure very attractive for synthesis.

引用

页码：4479 / 4488

页数：10

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