Emerging insights into natural killer cells in human peripheral tissues

被引：345
作者：
Bjorkstrom, Niklas K. [1 ]
Ljunggren, Hans-Gustaf [1 ]
Michaelsson, Jakob [1 ]
机构：
[1] Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, S-14186 Stockholm, Sweden
来源：
NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 05期
基金：
瑞典研究理事会;
关键词：
INNATE LYMPHOID-CELLS; MEMORY T-CELLS; DECIDUAL NK CELLS; INFLUENZA-VIRUS INFECTION; HEPATIC STELLATE CELLS; RESIDENT MEMORY; CYTOMEGALOVIRUS-INFECTION; UNIQUE SUBSET; HEPATOCELLULAR-CARCINOMA; INHIBITORY RECEPTORS;
D O I：
10.1038/nri.2016.34
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NK) cells have long been considered to be a homogenous population of innate lymphocytes with limited phenotypic and functional diversity. However, recent findings have revealed that these cells comprise a large number of distinct populations with diverse characteristics. Some of these characteristics may relate to their developmental origin, and others represent differences in differentiation that are influenced by factors such as tissue localization and imprints by viral infections. In this Review, we provide a comprehensive overview of the emerging knowledge about the development, differentiation and function of human NK cell populations, with a particular focus on NK cells in peripheral tissues.
引用
收藏
页码：310 / 320
页数：11
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