Emerging insights into natural killer cells in human peripheral tissues

被引：335
作者：
Bjorkstrom, Niklas K. [1 ]
Ljunggren, Hans-Gustaf [1 ]
Michaelsson, Jakob [1 ]
机构：
[1] Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, S-14186 Stockholm, Sweden
来源：
NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 05期
基金：
瑞典研究理事会;
关键词：
INNATE LYMPHOID-CELLS; MEMORY T-CELLS; DECIDUAL NK CELLS; INFLUENZA-VIRUS INFECTION; HEPATIC STELLATE CELLS; RESIDENT MEMORY; CYTOMEGALOVIRUS-INFECTION; UNIQUE SUBSET; HEPATOCELLULAR-CARCINOMA; INHIBITORY RECEPTORS;
D O I：
10.1038/nri.2016.34
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NK) cells have long been considered to be a homogenous population of innate lymphocytes with limited phenotypic and functional diversity. However, recent findings have revealed that these cells comprise a large number of distinct populations with diverse characteristics. Some of these characteristics may relate to their developmental origin, and others represent differences in differentiation that are influenced by factors such as tissue localization and imprints by viral infections. In this Review, we provide a comprehensive overview of the emerging knowledge about the development, differentiation and function of human NK cell populations, with a particular focus on NK cells in peripheral tissues.
引用
收藏
页码：310 / 320
页数：11
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  • [11] Molecular Mechanisms of Natural Killer Cell Activation
    Bryceson, Yenan T.
    Chiang, Samuel C. C.
    Darmanin, Stephanie
    Fauriat, Cyril
    Schlums, Heinrich
    Theorell, Jakob
    Wood, Stephanie M.
    [J]. JOURNAL OF INNATE IMMUNITY, 2011, 3 (03) : 216 - 226
  • [12] The Lytic Potential of Human Liver NK Cells Is Restricted by Their Limited Expression of Inhibitory Killer Ig-Like Receptors
    Burt, Bryan M.
    Plitas, George
    Zhao, Zeguo
    Bamboat, Zubin M.
    Nguyen, Hoang M.
    Dupont, Bo
    DeMatteo, Ronald P.
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (03) : 1789 - 1796
  • [13] Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs
    Carbone, Francis R.
    [J]. JOURNAL OF IMMUNOLOGY, 2015, 195 (01) : 17 - 22
  • [14] Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56BrightCD16- cells and display an impaired capability to kill tumor cells
    Carrega, Paolo
    Morandi, Barbara
    Costa, Roberta
    Frumento, Guido
    Forte, Giuseppe
    Altavilla, Giuseppe
    Ratto, Giovanni Battista
    Mingari, Maria Cristina
    Moretta, Lorenzo
    Ferlazzo, Guido
    [J]. CANCER, 2008, 112 (04) : 863 - 875
  • [15] CD56(bright) natural killer cell subsets: Characterization of distinct functional responses to interleukin-2 and the c-kit ligand
    Carson, WE
    Fehniger, TA
    Caligiuri, MA
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (02) : 354 - 360
  • [16] Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors:: Consequences for the NK-mediated killing of dendritic cells
    Castriconi, R
    Cantoni, C
    Della Chiesa, M
    Vitale, M
    Marcenaro, E
    Conte, R
    Biassoni, R
    Bottino, C
    Moretta, L
    Moretta, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 4120 - 4125
  • [17] ADHESION BETWEEN EPITHELIAL-CELLS AND T-LYMPHOCYTES MEDIATED BY E-CADHERIN AND THE ALPHA(E)BETA(7) INTEGRIN
    CEPEK, KL
    SHAW, SK
    PARKER, CM
    RUSSELL, GJ
    MORROW, JS
    RIMM, DL
    BRENNER, MB
    [J]. NATURE, 1994, 372 (6502) : 190 - 193
  • [18] Conversion of Peripheral Blood NK Cells to a Decidual NK-like Phenotype by a Cocktail of Defined Factors
    Cerdeira, Ana Sofia
    Rajakumar, Augustine
    Royle, Caroline M.
    Lo, Agnes
    Husain, Zaheed
    Thadhani, Ravi I.
    Sukhatme, Vikas P.
    Karumanchi, S. Ananth
    Kopcow, Hernan D.
    [J]. JOURNAL OF IMMUNOLOGY, 2013, 190 (08) : 3939 - 3948
  • [19] Lamina propria c-kit+ immune precursors reside in human adult intestine and differentiate into natural killer cells
    Chinen, Hiroshi
    Matsuoka, Katsuyoshi
    Sato, Toshiro
    Kamada, Nobuhiko
    Okamoto, Susumu
    Hisamatsu, Tadakazu
    Kobayashi, Taku
    Hasegawa, Hirotoshi
    Sugita, Akira
    Kinjo, Fukunori
    Fujita, Jiro
    Hibi, Toshifumi
    [J]. GASTROENTEROLOGY, 2007, 133 (02) : 559 - 573
  • [20] Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients
    Clark, Rachael A.
    Watanabe, Rei
    Teague, Jessica E.
    Schlapbach, Christoph
    Tawa, Marianne C.
    Adams, Natalie
    Dorosario, Andrew A.
    Chaney, Keri S.
    Cutler, Corey S.
    LeBoeuf, Nicole R.
    Carter, Joi B.
    Fisher, David C.
    Kupper, Thomas S.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (117)
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