Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

被引：79

作者：

Hectors, Stefanie J. ^{[1
,2
]}

Wagner, Mathilde ^{[1
,2
,3
]}

Bane, Octavia ^{[1
,2
]}

Besa, Cecilia ^{[1
,2
]}

Lewis, Sara ^{[1
,2
]}

Remark, Romain ^{[4
]}

Chen, Nelson ^{[1
,2
]}

Fiel, M. Isabel ^{[5
]}

Zhu, Hongfa ^{[5
]}

Gnjatic, Sacha ^{[6
]}

Merad, Miriam ^{[4
]}

Hoshida, Yujin ^{[7
]}

Taouli, Bachir ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA

[3] UPMC, Sorbonne Univ, Hop Pitie Salpetriere, AP HP,Dept Radiol, Paris, France

[4] Icahn Sch Med Mt Sinai, Immunol Inst, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Oncol Sci, New York, NY 10029 USA

[7] Icahn Sch Med Mt Sinai, Dept Med, Div Liver Dis, New York, NY 10029 USA

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

GENE-EXPRESSION PROGRAMS; DCE-MRI; PERFUSION QUANTIFICATION; TUMOR HETEROGENEITY; LIVER; CANCER; CELLS; IMMUNOTHERAPY; TREMELIMUMAB; PARAMETERS;

D O I：

10.1038/s41598-017-02706-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumour heterogeneity poses a significant challenge for treatment stratification. The goals of this study were to quantify heterogeneity in hepatocellular carcinoma (HCC) using multiparametric magnetic resonance imaging (mpMRI), and to report preliminary data correlating quantitative MRI parameters with advanced histopathology and gene expression in a patient subset. Thirty-two HCC patients with 39 HCC lesions underwent mpMRI including diffusion-weighted imaging (DWI), blood-oxygenation-level-dependent (BOLD), tissue-oxygenation-level-dependent (TOLD) and dynamic contrast-enhanced (DCE)-MRI. Histogram characteristics [central tendency (mean, median) and heterogeneity (standard deviation, kurtosis, skewness) MRI parameters] in HCC and liver parenchyma were compared using Wilcoxon signed-rank tests. Histogram data was correlated between MRI methods in all patients and with histopathology and gene expression in 14 patients. HCCs exhibited significantly higher intra-tissue heterogeneity vs. liver with all MRI methods (P < 0.030). Although central tendency parameters showed significant correlations between MRI methods and with each of histopathology and gene expression, heterogeneity parameters exhibited additional complementary correlations between BOLD and DCE-MRI and with histopathologic hypoxia marker HIF1 alpha and gene expression of Wnt target GLUL, pharmacological target FGFR4, stemness markers EPCAM and KRT19 and immune checkpoint PDCD1. Histogram analysis combining central tendency and heterogeneity mpMRI features is promising for non-invasive HCC characterization on the imaging, histologic and genomics levels.

引用

页数：12

共 58 条

[1] MR Imaging Biomarkers in Oncology Clinical Trials [J].