Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

被引:41
作者
Ktafke, Jonatas Zeni [2 ,3 ]
da Silva, Mariane Arnoldi [2 ,3 ]
Panigas, Tiago Facchini [2 ]
Belli, Karlyse Claudino [2 ]
de Oliveira, Marileides Facco [3 ]
Barichello, Marcia Meister [3 ]
Rigo, Flavia Karine
Rossato, Mateus Fortes
Soares dos Santos, Adair Roberto [4 ]
Pizzolatti, Moacir Geraldo [5 ]
Ferreira, Juliano [1 ]
Nazario Viecili, Paulo Ricardo [2 ,3 ]
机构
[1] Univ Fed Santa Maria, Dept Quim, Programa Posgrad Ciencias Biol Bioquim Toxicol, BR-97105900 Santa Maria, RS, Brazil
[2] Inst Cardiol Cruz Alta, Cruz Alta, RS, Brazil
[3] Univ Cruz Alta, Cruz Alta, RS, Brazil
[4] Univ Fed Santa Catarina, Dept Physiol Sci, Florianopolis, SC, Brazil
[5] Univ Fed Santa Catarina, Dept Chem, Florianopolis, SC, Brazil
关键词
3-Hydroxy-3-methylglutaryl coenzyme A reductase; Campomanesia xanthocarpa; Hypercholesterolemia; Medicinal plant; Myrtaceae; Protein carbonyl; RISK-FACTORS; REDUCTASE DEREGULATION; CHOLESTEROL; EXTRACT;
D O I
10.1016/j.jep.2009.11.004
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ethnopharmacological relevance: In Southern Brazil, the plant Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known as "guavirova", has been empirically used for its potential effect in reducing blood cholesterol levels. Aim of the study: Since there are no scientific data confirming its popular use, the aim of the present study was to investigate the effect of Campomanesia xanthocarpa on biochemical, hematological, anthropometrical and oxidative stress parameters in hypercholesterolemic patients. Materials and methods: Thirty three patients were selected according to total cholesterol (TC) levels: 200-240mg/dL, undesirable level (UL), and >240mg/dL hypercholesterolemic level (HL). UL or HL patients were randomly divided into control group (CC), which received placebo capsules, and experimental group 250 (EG 250) or 500 (EG 500), which received either 250 or 500mg of encapsulated Campomanesia xanthocarpa. All groups received a cholesterol restriction diet and capsules once a day. The biochemical (TC, triglycerides, HDL, LDL and VLDL), hematological (hematocrit and hemoglobin), anthropometrical (weight and abdominal circumference) and oxidative stress (protein carbonyl) parameters were measured before. 45 and 90 days after the treatment started. Results: There was no alteration on biochemical, hematological, anthropometric or oxidative stress parameters in UL patients of all groups. However, a significant decrease in TC and LDL levels was observed in HL patients from EG 500 group (reduction of 28 +/- 3% and 45 +/- 4% to levels before treatment) in relation to CC group patients (reduction of 12 +/- 2% and 29 +/- 4%). Moreover, a significant reduction in oxidative stress was observed in HL patients of EG 250 (51 +/- 12%) and EG 500 groups (34 +/- 18%) when compared to levels before treatment. A positive correlation between plasma oxidative stress PC and TC levels was observed. Finally, we found that Campomanesia xanthocarpa extract possesses anti-oxidant properties and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitory activity in vitro. Conclusion: Confirming its popular use, the treatment with Campomanesia xanthocarpa encapsulated reduced blood TC and LDL levels in hypercholesterolemic patients. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:299 / 305
页数:7
相关论文
共 34 条
[1]   New method for the quantitative determination of major protein carbonyls, α-aminoadipic and γ-glutamic semialdehydes:: Investigation of the formation mechanism and chemical nature in vitro and in vivo [J].
Akagawa, Mitsugu ;
Sasaki, Daisuke ;
Ishii, Yoshihisa ;
Kurota, Yayoi ;
Yotsu-Yamashita, Mari ;
Uchida, Koji ;
Suyama, Kyozo .
CHEMICAL RESEARCH IN TOXICOLOGY, 2006, 19 (08) :1059-1065
[2]   Treatment of high-risk older persons with lipid-lowering drug therapy [J].
Aronow, Wilbert S. .
AMERICAN JOURNAL OF THERAPEUTICS, 2008, 15 (02) :102-107
[3]   Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men [J].
Austin, MA ;
Rodriguez, BL ;
McKnight, B ;
McNeely, MJ ;
Edwards, KL ;
Curb, JD ;
Sharp, DS .
AMERICAN JOURNAL OF CARDIOLOGY, 2000, 86 (04) :412-416
[4]   International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis [J].
Bhatt, DL ;
Steg, PG ;
Ohman, EM ;
Hirsch, AT ;
Ikeda, Y ;
Mas, JL ;
Goto, S ;
Liau, CS ;
Richard, AJ ;
Röther, J ;
Wilson, PWF ;
Andersen-Dalheim, H ;
Anderson, P ;
Anell, B ;
Arber, S ;
Armstrong, K ;
Arnot, D ;
Baldam, A ;
Barratt, I ;
Barresi, S ;
Beder, J ;
Benson, M ;
Bergman, F ;
Best, J ;
Bhasim, R ;
Bovell, G ;
Bowman, N ;
Brkic, M ;
Bromberger, D ;
Brown, D ;
Brown, J ;
Brownstein, M ;
Bruce, A ;
Buonopane, J ;
Burns, S ;
Butler, A ;
Byrne, D ;
Carson, J ;
Cassimatis, P ;
Chaffey, G ;
Chambers, D ;
Chan, WJ ;
Chan, B ;
Cheatham, J ;
Chen, R ;
Cheong, B ;
Cheung, C ;
Chin, J ;
Chiu, A ;
Choo, E .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (02) :180-189
[5]   Preliminary studies on Campomanesia xanthocarpa (Berg.) and Cuphea carthagenensis (Jacq.) JF Macbr. aqueous extract:: weight control and biochemical parameters [J].
Biavatti, MW ;
Farias, C ;
Curtius, F ;
Brasil, LM ;
Hort, S ;
Schuster, L ;
Leite, SN ;
Prado, SRT .
JOURNAL OF ETHNOPHARMACOLOGY, 2004, 93 (2-3) :385-389
[6]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[7]  
COHN SH, 1987, VIVO BODY COMPOSITIO, P1
[8]   Biomarkers of oxidative damage in human disease [J].
Dalle-Donne, I ;
Rossi, R ;
Colombo, R ;
Giustarini, D ;
Milzani, A .
CLINICAL CHEMISTRY, 2006, 52 (04) :601-623
[9]   Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction - Final report of the Lyon Diet Heart Study [J].
de Lorgeril, M ;
Salen, P ;
Martin, JL ;
Monjaud, I ;
Delaye, J ;
Mamelle, N .
CIRCULATION, 1999, 99 (06) :779-785
[10]   Plants popularly used for loosing weight purposes in Porto Alegre, South Brazil [J].
Dickel, Michele Luciane ;
Kuze Rates, Stela Maris ;
Ritter, Mara Rejane .
JOURNAL OF ETHNOPHARMACOLOGY, 2007, 109 (01) :60-71