Loss of CD28 expression on T lymphocytes: A marker of replicative senescence

被引：133

作者：

Effros, RB ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1997年 / 21卷 / 06期

关键词：

aging; T-cells; replicative senescence; CD28; immune exhaustion; telomeres;

D O I：

10.1016/S0145-305X(97)00027-X

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The CD28 molecule, a disulfide-linked homodimer expressed on peripheral T cells and thymocytes, mediates an essential costimulatory signal following engagement of the T cell receptor (TCR). Increased proportions of CD28 - T cells have been observed during aging and in situations of chronic immune stimulation, but the origin and functional characteristics of these cells have been unclear. T cells which reach replicative senescence in culture after multiple rounds of cell division have shortened telomeres, respond poorly to stress stimuli, and no longer express CD28, suggesting that CD28 - T cells observed in vivo may be the progeny of memory cells which have been repeatedly stimulated. This review describes the features of T cell replicative senescence, presents several possible mechanisms for the generation of senescent T cells in vivo, and proposes that replicative senescence may explain immune exhaustion. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：471 / 478

页数：8

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